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Several noninvasive markers for fibrosis, including blood\u2010based markers and imaging based\u2010markers have been developed. Indirect fibrosis markers (e.g., fibrosis\u20104 index and NAFLD fibrosis score) consist of standard laboratory data and clinical parameters. Given its availability and high negative predictive value for advanced fibrosis, these markers are suitable for screening at primary care. Blood\u2010based fibrogenesis markers (enhanced liver fibrosis and N\u2010terminal propeptide of type 3 collagen), ultrasound\u2010based modalities (vibration\u2010controlled transient elastography, point shear wave elastography [SWE], and two\u2010dimensional SWE), and magnetic resonance elastography have high diagnostic accuracy for liver fibrosis and are suitable for diagnosing liver fibrosis at secondary care centers. Sequential use of these markers can increase diagnostic accuracy and reduce health care costs. Furthermore, combining noninvasive makers may assist in identifying candidates for pharmacological trials and reducing screening failure. Emerging data suggest that these noninvasive markers are associated with liver\u2010related events (hepatocellular carcinoma and decompensation) and mortality. Furthermore, delta change in noninvasive markers over time is also associated with time\u2010course change in fibrosis, liver\u2010related event risk, and mortality risk. However, the association between liver fibrosis and cardiovascular disease (CVD) risk is still controversial. CVD risk may decrease in patients with decompensated liver disease and noninvasive markers may be useful for assessing CVD risk in these patients. 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