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We retrospectively investigated the relationship between FLI and the development of ischemic heart disease (IHD) during a 10\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among subjects who received annual health checkups (<jats:italic>n<\/jats:italic>\u00a0= 28 990), a total of 18\u00a0851 subjects (men\/women: 11\u00a0659\/7192) were enrolled after exclusion of subjects with missing data and those with IHD at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FLI at baseline was significantly higher in men than in women. During the 10\u2010year period, 450 men (3.9%) and 123 women (1.7%) had new onset of IHD determined by a self\u2010reported questionnaire survey. Multivariable Cox proportional hazard models with a restricted cubic spline showed that hazard risk (HR) for the development of IHD increased with a higher FLI at baseline after adjustment of age, sex, current smoking habit, family history of IHD and diagnosis of diabetes mellitus, hypertension, dyslipidemia and chronic kidney disease at baseline. There was no significant interaction between FLI and sex for the adjusted HR. When divided by tertiles of FLI at baseline (T1\u223cT3), the adjusted risk for development of IHD in the T3 group (HR [95% confidence interval]: 1.34 [1.05\u20131.71]) was significantly higher than that in the T1 group as the reference. The addition of FLI into traditional risk factors for IHD significantly improved the discriminatory capability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A high level of FLI is an independent predictor of new onset of IHD during a 10\u2010year period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13790","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T09:24:16Z","timestamp":1652693056000},"page":"687-698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["High fatty liver index is an independent predictor of ischemic heart disease during a 10\u2010year period in a Japanese population"],"prefix":"10.1111","volume":"52","author":[{"given":"Kazuma","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Cardiovascular, Renal and Metabolic Medicine Sapporo Medical University School of Medicine  Sapporo Japan"},{"name":"Department of 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