{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:09:29Z","timestamp":1769753369556,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["20HC2002"],"award-info":[{"award-number":["20HC2002"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["JPMH19HC1001"],"award-info":[{"award-number":["JPMH19HC1001"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20fk0210067h0001"],"award-info":[{"award-number":["JP20fk0210067h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/aim<\/jats:title><jats:p>Antiviral therapy advancements resulted in an era in which eradication of hepatitis C has become a goal, however, there are few reports on the long\u2010term course of liver disease progression with antiviral therapy. The aim of this study was to use the Markov model to analyze disease progression and non\u2010invasive liver fibrosis index in hepatitis C Patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with chronic hepatitis C (<jats:italic>n<\/jats:italic>\u00a0=\u00a01432) were diagnosed between January 2012 and May 2021 in the Musashino Red Cross Hospital. Patients with other hepatitis virus co\u2010infection, chronic liver disease, and hepatocellular carcinoma (HCC) at the beginning of the study were excluded. A total of 618 patients with a 1\u2010year or longer observation period were studied. The liver disease state was defined as chronic hepatitis (CH), compensated liver cirrhosis (CLC), decompensated liver cirrhosis (DLC), and HCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cirrhosis and high FIB\u20104 index (\u22653.61) were 42 cases (6.8%) and 208 cases (33.6%), respectively at the start of the study. The 40\u00a0years estimated transition analysis of 40\u2010year\u2010old CH low FIB\u20104 level (&lt;3.61) revealed that the proportion of CH low\/high, CLC low\/high, DLC low\/high, and HCC were 10.83%\/10.86%, 0.35%\/2.64%, 0%\/3.21% 72.11% in untreated unit and 47.83%\/9.21%, 6.69%\/1.32%, 0.70%\/0.99%, 33.27% in treated unit, respectively. Antiviral therapy suppressed liver fibrosis, disease progression, and HCC development significantly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Markov model analysis of hepatitis C virus patients showed the impact of antiviral therapy on the suppression of disease progression in the order of CH, CLC, and DLC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13794","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T05:19:45Z","timestamp":1653023985000},"page":"665-676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of antiviral therapy for disease progression and non\u2010invasive liver fibrosis index in patients with chronic hepatitis C: Markov chain model analysis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2660-6580","authenticated-orcid":false,"given":"Shun","family":"Kaneko","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Musashino Red Cross Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7016-8931","authenticated-orcid":false,"given":"Masayuki","family":"Kurosaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Musashino Red Cross Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akemi","family":"Kurisu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Infectious Disease Control and Prevention Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Akita","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Infectious Disease Control and Prevention Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5669-4051","authenticated-orcid":false,"given":"Junko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Infectious Disease Control and Prevention Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Kanto","sequence":"additional","affiliation":[{"name":"Department of Liver Disease Research Center for Hepatitis and Immunology National Center for Global Health and Medicine  Chiba 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