{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:45:42Z","timestamp":1780573542674,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21fk0210058"],"award-info":[{"award-number":["JP21fk0210058"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>It is desirable to identify predictors of regression of liver fibrosis after achieving a sustained virologic response (SVR) by direct\u2010acting antiviral agents (DAAs) to antihepatitis C virus (HCV) therapy. Here, we retrospectively investigated the serum angiopoietin\u20102 (Ang\u20102) level as a predictive indicator of regression of liver fibrosis after successful HCV eradication by DAA therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study subjects were recruited from a historical cohort of 109 chronically HCV\u2010infected patients who had achieved SVR by DAA therapy and whose serum Mac\u20102 binding protein glycosylation isomer (M2BPGi) levels at baseline (before DAA therapy) were \u22652.0 the cut\u2010off index (COI). We defined patients with M2BPGi levels &lt;1.76 and\u00a0\u22651.76 COI at 2\u00a0years after the end of treatment (EOT) as the regression (R, <jats:italic>n<\/jats:italic>\u00a0=\u00a069) and nonregression (NR, <jats:italic>n<\/jats:italic>\u00a0=\u00a040) groups, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate analyses revealed that the Ang\u20102 level at baseline and the Ang\u20102 level, albumin\u2013bilirubin score, and FIB\u20104 index at 24\u00a0weeks after the EOT were significantly associated with regression of M2BPGi\u2010based liver fibrosis. Receiver operating characteristic curve analyses showed that the Ang\u20102 level at 24\u00a0weeks after the EOT had the largest area under the curve values (0.859). The same results were obtained even when the serum M2BPGi levels were aligned by propensity score matching and in patients with advanced M2BPGi\u2010based liver fibrosis: M2BPGi levels \u22653.3 COI at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The serum Ang\u20102 level at 24\u00a0weeks after the EOT is a feasible predictor of regression of M2BPGi\u2010based liver fibrosis after achieving SVR by DAA therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13823","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T10:34:58Z","timestamp":1659954898000},"page":"919-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Serum angiopoietin\u20102 levels predict regression of Mac\u20102 binding protein glycosylation isomer\u2010based liver fibrosis after hepatitis C virus eradication by direct\u2010acting antiviral agents"],"prefix":"10.1111","volume":"52","author":[{"given":"Takanori","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihito","family":"Nagura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Virology Nagoya City University Graduate School of Medical Sciences  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