{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:25:55Z","timestamp":1774416355197,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The association between thrombolytic therapy and the outcome in patients with portal vein thrombosis (PVT) remains controversial. This study aimed to evaluate the outcome in patients with PVT who received antithrombin\u00a0III\u2010based therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a retrospective, multicenter study to investigate the liver\u2010related events and the survival rates in 240 patients with PVT who received the therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients comprised 151 men and 89 women, with a median age of 69\u00a0years. The rate of favorable response, defined as maximum area of PVT changed to \u226475%, was 67.5% (162\/240). The cumulative rates of liver\u2010related events at 1, 2, and 3\u00a0years were 38.2%, 53.9%, and 68.5%, respectively. The multivariate analysis showed that viable hepatocellular carcinoma, absence of maintenance therapy, non\u2010responder, and PVT progression were significantly associated with liver\u2010related events. The PVT progression was observed in 23.3% (56\/240). The multivariate analysis identified older age, absence of maintenance therapy, and non\u2010responder as independent factors associated with PVT progression. The multivariate analysis revealed that younger age, no hepatocellular carcinoma, presence of maintenance therapy, and lower Model for End\u2010stage Liver Disease\u2010Sodium score significantly contributed to 3\u2010year survival. Of the 240 patients, 13 (8.9%) prematurely discontinued treatment due to any adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that maintenance therapy, favorable response, and absence of PVT progression may suppress or control liver\u2010related events in antithrombin\u00a0III\u2010based therapy for patients with PVT. Specifically, maintenance therapy could suppress not only liver\u2010related events, but also PVT progression and improve the prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13840","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T17:04:55Z","timestamp":1663866295000},"page":"51-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical outcomes of antithrombin\u00a0III\u2010based therapy for patients with portal vein thrombosis: A retrospective, multicenter study"],"prefix":"10.1111","volume":"53","author":[{"given":"Korenobu","family":"Hayama","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School Chiba Hokusoh Hospital  Inzai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Atsukawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School Chiba 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