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However, in the absence of an appropriate animal experimental model, little is known about its pathophysiology. This study aimed to establish a clinically relevant reproducible model of FOLFOX\u2010induced SOS and to compare the clinical\/histopathological features between the clinical and animal SOS settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed clinical\/pathological analyses of colorectal liver metastasis (CRLM) patients who underwent hepatectomy with\/without preoperative treatment of FOLFOX (<jats:italic>n<\/jats:italic>\u00a0=\u00a022\/18). Male micro\u2010minipigs were treated with 50% of the standard human dosage of the FOLFOX regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In contrast to the monocrotaline\u2010induced SOS model in rats, hepatomegaly, ascites, congestion, and coagulative necrosis of hepatocytes were absent in patients with CRLM with OXCx pretreatment and OXCx\u2010treated micro\u2010minipigs. In parallel to CRLM cases with OXCx pretreatment, OXCx\u2010challenged micro\u2010minipigs exhibited deteriorated indocyanine green clearance, morphological alteration of liver sinusoidal endothelial cells, and upregulated matrix metalloproteinase\u20109. Using our novel porcine SOS model, we identified the hepatoprotective influence of recombinant human soluble thrombomodulin in OXCx\u2010SOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>With distinct differences between monocrotaline\u2010induced rat SOS and human\/pig OXCx\u2010SOS, our pig OXCx\u2010SOS model serves as a preclinical platform for future investigations to dissect the pathophysiology of OXCx\u2010SOS and seek preventive strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13842","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T14:53:50Z","timestamp":1663944830000},"page":"145-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinically relevant model of oxaliplatin\u2010induced sinusoidal obstruction syndrome"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3532-8930","authenticated-orcid":false,"given":"Rei","family":"Toda","sequence":"first","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Uemoto","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koshiro","family":"Morino","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Nishino","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5542-0163","authenticated-orcid":false,"given":"Naohiko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Surgery Kanazawa Medical University  Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Okuno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Hyogo Medical University  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohta","family":"Iguchi","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medicine &amp; 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