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Serum creatinine has several limitations as a stand\u2010alone marker of AKI in patients with decompensated CLD. The concept of hepatorenal syndrome, the prototype of AKI in decompensated CLD, has evolved tremendously over recent years. There is emerging evidence of an additional \u201cstructural\u201d component in the pathophysiology of hepatorenal syndrome\u2010AKI, which was previously identified as a purely \u201cfunctional\u201d form of renal impairment. Lacunae in the existent biochemical arsenal for diagnosis and prognosis of AKI have fueled enthusiastic research in the field of novel biomarkers of kidney injury in patients with cirrhosis. The advent of these biomarkers provides a crucial window of opportunity to improve the diagnosis and clinical outcomes of this vulnerable cohort of patients. This review summarizes the dynamic concept of renal dysfunction in CLD and the available literature on the role of novel biomarkers of AKI in assessing renal function, identifying AKI subtypes, and predicting prognosis. There is special emphasis on the renal tubular injury marker, neutrophil gelatinase\u2010associated lipocalin, the most exhaustively studied biomarker of AKI in the CLD population.<\/jats:p>","DOI":"10.1111\/hepr.13847","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T05:34:26Z","timestamp":1666244066000},"page":"3-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Novel biomarkers of acute kidney injury in chronic liver disease: Where do we stand after a decade of research?"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9658-6848","authenticated-orcid":false,"given":"Rohan Vijay","family":"Yewale","sequence":"first","affiliation":[{"name":"Institute of Gastroenterology, Hepatobiliary Sciences and Transplantation SRM Institutes for Medical Science  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5090-9501","authenticated-orcid":false,"given":"Balakrishnan Siddartha","family":"Ramakrishna","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Hepatobiliary Sciences and Transplantation SRM Institutes for Medical Science  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/gox009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.03.039"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/ghep.ghep_9_20","article-title":"Renal dysfunction in chronic liver disease: current concepts, classification, and management","volume":"1","author":"Yewale R","year":"2020","journal-title":"Gastroenterol Hepatol Endosc 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