{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T03:39:50Z","timestamp":1786592390582,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Few studies have reported the efficacy and safety of ramucirumab (RAM) after atezolizumab plus bevacizumab (Atezo\/Beva) treatment and the overall associated outcomes. Thus, we aimed to evaluate the therapeutic effects and safety of RAM post\u2010treatment with Atezo\/Beva.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study enrolled 46 patients with unresectable hepatocellular carcinoma who were treated with RAM. The patients were classified into the RAM administered following Atezo\/Beva failure (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) or RAM administered following other drug failure (<jats:italic>n<\/jats:italic>\u00a0=\u00a034) groups. Progression\u2010free survival (PFS), overall survival (OS), and adverse event (AE) rates were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant differences in the objective response rates and disease control rates between the RAM administered following Atezo\/Beva and RAM administered following others groups (objective response rate 33.3%. vs. 0.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001; disease control rate 83.3% vs. 32.3, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). Although there was no significant difference in the OS rates, the median PFS rates in the RAM administered following Atezo\/Beva group was significantly higher than in the RAM administered following others group (PFS 3.9\u00a0months. vs. 1.9\u00a0months, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.047). The AE rates were comparable between the two groups; ascites was the most common AE (45.6%). Using decision tree analysis, the presence of splenomegaly and body mass index (BMI)\u00a0&lt;\u00a019.8 were the first and second splitting variables for RAM\u2010related ascites, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The therapeutic effect of RAM increased in patients with Atezo\/Beva failure. Patients with splenomegaly and low BMI should be monitored for ascites during RAM treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13852","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T04:29:47Z","timestamp":1667276987000},"page":"116-126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Significance of ramucirumab following atezolizumab plus bevacizumab therapy for hepatocellular carcinoma using real\u2010world data"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2068-8386","authenticated-orcid":false,"given":"Shigeo","family":"Shimose","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of 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