{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:10:25Z","timestamp":1785168625872,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Cell\u2010free and concentrated ascites reinfusion therapy (CART) and large\u2010volume paracentesis (LVP) with albumin infusion are useful for managing refractory ascites (RA). However, it remains unclear which therapy is more effective in patients with cirrhosis with RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From June 2018 to March 2022, 25 patients with RA treated with CART or LVP with albumin infusion were enrolled in this multicenter prospective observational study to investigate the number of abdominal paracenteses, albumin preparations used, and drainage volume during an 8\u2010week observation period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among all patients at entry (median age, 63\u00a0years; 52% men; 60% Child\u2013Pugh B and 40% Child\u2013Pugh C), 92% were treated with furosemide (median, 20\u00a0mg\/day), 92% with spironolactone (25\u00a0mg\/day), and all with tolvaptan (7.5\u00a0mg\/day). Patients with RA had a poor health\u2010related quality of life (HRQOL) and prominent ascites\u2010related symptoms. Four of the 20 eligible patients were treated with CART, 11 with LVP with albumin infusion, and five with their combination. The median number of paracenteses, total drainage volume, and albumin infusions were 1.5, 7.4\u00a0L, and 0, respectively, in the CART group; 5.0, 22.0\u00a0L, and 5.0, respectively, in the LVP group; and 5.0, 30.0\u00a0L, and 5.0, respectively in their combination group. The treatment effects did not differ significantly among the three groups regarding weight loss, liver function, renal function, electrolytes, and HRQOL. However, patients treated with CART had fewer paracenteses and albumin infusions than those treated with LVP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CART and LVP have comparable therapeutic efficacy for RA in patients with cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13860","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T13:18:17Z","timestamp":1669382297000},"page":"238-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cell\u2010free and concentrated ascites reinfusion therapy versus large\u2010volume paracentesis for the treatment of cirrhotic patients with refractory ascites: A multicenter prospective observational study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7797-9534","authenticated-orcid":false,"given":"Tatsunori","family":"Hanai","sequence":"first","affiliation":[{"name":"Department of Gastroenterology\/Internal Medicine Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Kawaratani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Nagano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Gifu Prefectural General Medical Center  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Suii","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sapporo Kosei General Hospital  Sapporo Hokkaido 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University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Okubo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Nippon Medical School Chibahokusoh Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6373-260X","authenticated-orcid":false,"given":"Takao","family":"Miwa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology\/Internal Medicine Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Gifu Prefectural General Medical Center  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Hige","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sapporo 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