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Imaging modalities provided clinical evidence that elevation of liver stiffness and tumor occurrence are mainly induced in the periphery of the liver in patients with congestive hepatopathy. However, clinical relevance of liver stiffness and liver fibrosis is unclear because liver congestion itself increases liver stiffness in congestive hepatopathy. It also unclear which factors configure such regional disparity of tumor development in patients with congestive hepatopathy. To answer these questions, we evaluated the macroscopic spatial distribution of liver fibrosis and tumors in the murine model of congestive hepatopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Chronic liver congestion was induced by partial ligation of the suprahepatic inferior vena cava. Distribution of liver congestion, fibrosis, and tumors in partial ligation of the suprahepatic inferior vena cava mice were assessed by histological findings, laser microdissection (LMD)\u2010based qPCR and enhanced computed tomography. LMD\u2010based RNA\u2010sequencing was performed to identify causal factors that promote tumor development in congestive hepatopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Liver fibrosis was mainly induced in the periphery of the liver and co\u2010localized with distribution of liver congestion. Liver tumors were also induced in the periphery of the liver where liver congestion and fibrosis occurred. LMD\u2010based RNA\u2010sequencing revealed the upregulation of extracellular matrix\/collagen fibril\u2010, wound healing\u2010, angiogenesis\u2010, morphogenesis\u2010, and cell motility\u2010related signaling pathways in periphery of liver compared with liver center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings showed the experimental relevance of liver congestion, fibrosis, and tumor development in congestive hepatopathy, and may provide important locational information. Macroscopic regional disparity observed in this murine model should be considered to manage patients with congestive hepatopathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13866","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T11:11:10Z","timestamp":1670065870000},"page":"370-376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Peripheral\u2010dominant liver fibrosis and tumor distribution in a mouse model of congestive hepatopathy"],"prefix":"10.1111","volume":"53","author":[{"given":"Hironari","family":"Kawai","sequence":"first","affiliation":[{"name":"The Research Center for Hepatitis and Immunology National Center for Global Health and Medicine  Ichikawa Chiba Japan"},{"name":"Department of Surgery The Jikei University School of Medicine  Minato\u2010ku Tokyo 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