{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:04:12Z","timestamp":1761897852120,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The antidiabetic drugs sodium glucose cotransporter 2 inhibitors (SGLT2is) and thiazolidinediones have beneficial effects on the liver dysfunction of patients with nonalcoholic fatty liver disease and type 2 diabetes mellitus (T2DM). We aimed to determine the efficacy of these drugs for the treatment of liver disease in patients with metabolic dysfunction\u2010associated fatty liver disease (MAFLD) and T2DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We undertook a retrospective study of 568 patients with MAFLD and T2DM. Of these, 210 were treating their T2DM with SGLT2is (<jats:italic>n<\/jats:italic>\u00a0=\u00a095), 86 with pioglitazone (PIO), and 29 with both. The primary outcome was the change in Fibrosis\u20104 (FIB\u20104) index between baseline and 96\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 96\u00a0weeks, the mean FIB\u20104 index had significantly decreased (from 1.79\u00a0\u00b1\u00a01.10\u20131.56\u00a0\u00b1\u00a00.75) in the SGLT2i group, but not in the PIO group. The aspartate aminotransferase to platelet ratio index, serum aspartate and alanine aminotransferase (ALT), hemoglobin A1c, and fasting blood sugar significantly decreased in both groups (ALT: SGLT2i group, \u221217\u00a0\u00b1\u00a03\u00a0IU\/L; PIO group, \u221214\u00a0\u00b1\u00a03\u00a0IU\/L). The bodyweight of the SGLT2i group decreased, but that of the PIO group increased (\u22123.2\u00a0kg and +1.7\u00a0kg, respectively). When the participants were allocated to two groups according to their baseline ALT (&gt;30\u00a0IU\/L), FIB\u20104 index significantly decreased in both groups. In patients taking pioglitazone, the addition of SGLT2i improved liver enzymes but not FIB\u20104 index for 96\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with SGLT2i causes a larger improvement in FIB\u20104 index than PIO in patients with MAFLD over 96\u00a0weeks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13898","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T09:59:32Z","timestamp":1678528772000},"page":"618-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of sodium glucose cotransporter 2 inhibitors and pioglitazone on FIB\u20104 index in metabolic\u2010associated fatty liver disease"],"prefix":"10.1111","volume":"53","author":[{"given":"Masaaki","family":"Mino","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology National Center for Global Health and Medicine Kohnodai Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Kakazu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology National Center for Global Health and Medicine Kohnodai Hospital  Chiba Japan"},{"name":"Division of Gastroenterology Tohoku University Graduate School of Medicine  Sendai Japan"},{"name":"Department of Liver Diseases The Research Center for Hepatitis and Immunology National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8185-247X","authenticated-orcid":false,"given":"Akitoshi","family":"Sano","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisayuki","family":"Katsuyama","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine Kohnodai Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Hakoshima","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine Kohnodai Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekatsu","family":"Yanai","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism National Center for Global Health and Medicine Kohnodai Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology National Center for Global Health and Medicine Kohnodai Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology National Center for Global Health and Medicine Kohnodai Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiji","family":"Yamazoe","sequence":"additional","affiliation":[{"name":"Department of Liver Diseases The Research Center for Hepatitis and Immunology National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taizo","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Liver Diseases The Research Center for Hepatitis and Immunology National Center for Global Health and Medicine  Tokyo 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