{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:12:17Z","timestamp":1791825137597,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22ck0106581h0003"],"award-info":[{"award-number":["JP22ck0106581h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to verify the therapeutic efficacy and safety of stereotactic body radiotherapy (SBRT) for previously untreated initial small hepatocellular carcinoma (HCC) in a multicenter, retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent SBRT for HCC at the Japanese Society of Clinical Oncology (JCOG) member hospitals in Japan between July 2013 and December 2017 and met the following eligibility criteria were included: (1) initial HCC; (2) \u22643 nodules, \u22645\u00a0cm in diameter; (3) Child\u2013Pugh score of A or B; and (4) unsuitability for or refusal of standard treatment. We analyzed the overall survival, recurrence\u2010free survival, and cumulative incidence of local recurrence rate, and adverse events directly related to SBRT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010three patients with 79 lesions from 14 hospitals were analyzed. The median age was 77\u00a0years (range: 50\u201389\u00a0years), and the median tumor size was 23\u00a0mm (range: 6\u201350\u00a0mm). The median radiation dose was 40\u00a0Gy (range: 35\u201360\u00a0Gy) in five fractions (range: 4\u20138). The median follow\u2010up period was 45\u00a0months (range: 0\u2013103\u00a0months). The 3\u2010year overall survival, recurrence\u2010free survival, and cumulative incidence of local recurrence rates were 69.9% (95% CI: 58.7%\u201381%), 57.9% (95% CI: 45.2%\u201370.5%), and 20.0% (95% CI: 11.2%\u201330.5%), respectively. Four cases (5.5%) of adverse events of grade 3 or higher were reported: three cases of grade 3 and one case of grade 4 (duodenal ulcer). No grade 5 toxicities were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SBRT is a promising treatment modality, particularly for small HCCs, as they are not suitable for standard treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13908","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T12:28:40Z","timestamp":1681129720000},"page":"749-760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multicenter retrospective study of stereotactic body radiotherapy for patients with previously untreated initial small hepatocellular carcinoma"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0047-994X","authenticated-orcid":false,"given":"Yoshiko","family":"Doi","sequence":"first","affiliation":[{"name":"Hiroshima High\u2010Precision Radiotherapy Cancer Center  Hiroshima Japan"},{"name":"Department of Radiation 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