{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:18:30Z","timestamp":1769595510480,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573258"],"award-info":[{"award-number":["81573258"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to evaluate the cost\u2010effectiveness of hepatitis E vaccination strategies in chronic hepatitis B (CHB) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on the societal perspective, the cost\u2010effectiveness of three hepatitis E vaccination strategies\u2014vaccination without screening, screening\u2010based vaccination, and no vaccination\u2014among CHB patients was evaluated using a decision tree\u2013Markov model, and incremental cost\u2010effectiveness ratios (ICERs) were calculated. Values for treatment costs and health utilities were estimated from a prior investigation on disease burden, and values for transition probabilities and vaccination\u2010related costs were obtained from previous studies and government agencies. Sensitivity analyses were undertaken for assessing model uncertainties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>It was estimated that CHB patients superinfected with hepatitis E virus (HEV) incurred significantly longer disease course, higher economic burden, and more health loss compared to those with HEV infection alone (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The ICERs of vaccination without screening and screening\u2010based vaccination compared to no vaccination were 41,843.01 yuan\/quality\u2010adjusted life year (QALY) and 29,147.32 yuan\/QALY, respectively, both lower than China's per\u2010capita gross domestic product (GDP) in 2018. The screening\u2010based vaccination reduced the cost and gained more QALYs than vaccination without screening. One\u2010way sensitivity analyses revealed that vaccine price, vaccine protection rate, and decay rate of vaccine protection had the greatest impact on the cost\u2010effectiveness analysis. Probabilistic sensitivity analyses confirmed the base\u2010case results, and if the willingness\u2010to\u2010pay value reached per\u2010capita GDP, the probability that screening\u2010based vaccination would be cost\u2010effective was approaching 100%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The disease burden in CHB patients superinfected with HEV is relatively heavy in China, and the screening\u2010based hepatitis E vaccination strategy for CHB patients is the most cost\u2010effective option.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13967","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T17:17:02Z","timestamp":1694711822000},"page":"142-150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cost\u2010effectiveness analysis of hepatitis E vaccination strategies among patients with chronic hepatitis B in China"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8242-6045","authenticated-orcid":false,"given":"Tingting","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Southeast University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Center for Disease Control and Prevention  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Southeast University  Nanjing China"},{"name":"Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Southeast University  Nanjing China"},{"name":"Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changjun","family":"Bao","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Center for Disease Control and Prevention  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renjie","family":"Jiang","sequence":"additional","affiliation":[{"name":"Yancheng Center for Disease Control and Prevention  Yancheng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilin","family":"Xu","sequence":"additional","affiliation":[{"name":"Yancheng Center for Disease Control and Prevention  Yancheng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohu","family":"Yuan","sequence":"additional","affiliation":[{"name":"Zhenjiang Center for Disease Control and Prevention  Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunke","family":"Qian","sequence":"additional","affiliation":[{"name":"Zhenjiang Center for Disease Control and Prevention  Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liling","family":"Chen","sequence":"additional","affiliation":[{"name":"Suzhou Center for Disease Control and Prevention  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Hang","sequence":"additional","affiliation":[{"name":"Suzhou Center for Disease Control and Prevention  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanjing Center for Disease Control and 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