{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:37:19Z","timestamp":1784291839491,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Entecavir (ETV) and tenofovir alafenamide fumarate (TAF) are considered safe nucleoside\/nucleotide analogs (NA) for the kidney. This study aimed to investigate the long\u2010term effects of ETV or TAF on renal function in elderly patients with chronic hepatitis B (CHB) in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 246 CHB patients treated with ETV (184 patients) or TAF (62 patients) for at least 2\u00a0years. These patients were divided into two groups: those &lt;65\u00a0years of age (130 patients) and those \u226565\u00a0years of age (116 patients). The effects of the NAs on renal functions were examined by comparing the estimated glomerular filtration rates (eGFR) from baseline to 2\u00a0years between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The change in eGFR from baseline to 1 or 2\u00a0years after treatment was significantly decreased in both groups. However, the amount of change at 1 and 2\u00a0years was significantly greater in the group aged \u226565\u00a0years than in the group aged &lt;65\u00a0years. The amount of change in eGFR from baseline to 1 and 2\u00a0years after treatment was significantly greater in the group aged \u226565\u00a0years than in the group aged &lt;65\u00a0years, regardless of the type of NA, the prior treatment history, cirrhosis\/chronic hepatitis, hypertension, dyslipidemia, and diabetes. Additionally, logistic regression analysis showed that age \u226565\u00a0years was independently associated with a decreased eGFR after 2\u00a0years of NA treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term administration of NA to CHB patients over 65\u00a0years of age should be carefully monitored for renal impairment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13982","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T15:39:07Z","timestamp":1698507547000},"page":"252-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of entecavir and tenofovir alafenamide fumarate treatment on renal function in Japanese elderly patients with chronic hepatitis B"],"prefix":"10.1111","volume":"54","author":[{"given":"Misako","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Nara Medical 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