{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:12:08Z","timestamp":1792699928836,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Metabolic dysfunction\u2010associated fatty liver disease (MAFLD) is a major health concern. This cohort study aimed to evaluate the association between weight loss and remission of MAFLD in the Japanese population to aid the development of efficient treatment strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study was conducted at a Japanese health screening center. Participants included 3309 individuals diagnosed with baseline MAFLD between 2004 and 2016. Logistic regression analysis was used to assess the association between MAFLD remission from baseline to 5\u00a0years and weight change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 5\u00a0years, 671 participants achieved MAFLD remission. Weight loss was associated with MAFLD remission for every 1\u00a0kg of weight loss over 5\u00a0years; the odds ratio for MAFLD remission was 1.24 (95% CI 1.15\u20131.34) for participants with type\u00a02 diabetes, 1.40 (95% CI 1.35\u20131.45) for overweight participants, and 1.51 (95% CI 1.33\u20131.72) for non\u2010overweight participants with metabolic dysfunctions. The cutoff values for weight loss for MAFLD remission were 1.9\u00a0kg for all participants, 3.0\u00a0kg for participants with type\u00a02 diabetes, 1.9\u00a0kg for overweight participants, and 0.8\u00a0kg for non\u2010overweight participants with metabolic dysfunctions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among participants diagnosed with MAFLD, weight loss was associated with MAFLD remission regardless of the type of metabolic dysfunction in MAFLD. The results of this study may contribute to the development of novel approaches to achieve MAFLD remission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.13989","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T13:39:36Z","timestamp":1699450776000},"page":"336-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of weight loss on metabolic dysfunction\u2010associated fatty liver disease in Japanese people: Non\u2010alcoholic fatty liver disease in the Gifu area, longitudinal analysis study"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3435-6868","authenticated-orcid":false,"given":"Yuka","family":"Hasegawa","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto 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