{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:40:37Z","timestamp":1789508437166,"version":"build-2803163510"},"reference-count":8,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Primary sclerosing cholangitis (PSC) increases the risk of colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients; however, there is a paucity of literature to suggest PSC alone as an independent risk factor for CRC. We aimed to determine if PSC is an independent risk factor for CRC in a large tertiary care medical center. Optimizing screening intervals is of great importance, given the burden and risks associated with a lifetime of colonoscopy screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study consists of patients diagnosed with PSC preceding IBD (PSC\u2013IBD) and PSC\u2010only before January 6, 2023 from a large, tertiary, academic medical center. Patients diagnosed with IBD concurrently or before PSC were excluded to reduce IBD's impact on CRC risk. Demographic data and colonoscopy findings were collected and assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 140 patients from all NYU Langone Health clinical settings were included. Patients with PSC\u2013IBD were more likely to be diagnosed with CRC (23.3% vs. 1.8%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) and either low\u2010grade or uncharacterized dysplasia (16.7% vs. 0.0%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) compared with those with PSC\u2010only. Among PSC\u2010only patients, the estimated CRC risk was significantly elevated compared with that expected of the standard NYU Langone population (SIR 9.2, 95% CI 1.1, 33.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study revealed a significantly heightened CRC risk in PSC\u2013IBD patients compared with those with PSC\u2010only. Importantly, individuals with PSC\u2010only also face a greater CRC risk compared with the general population. Individuals with PSC\u2010alone may require extended screening and surveillance colonoscopy intervals compared with those with PSC\u2013IBD, yet still require more frequent monitoring than screening guidelines recommend for the general population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.14029","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T07:04:00Z","timestamp":1709190240000},"page":"807-816","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Risk of colorectal cancer in patients with primary sclerosing cholangitis and concomitant inflammatory bowel disease compared with primary sclerosing cholangitis only"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0814-4976","authenticated-orcid":false,"given":"Taranika Sarkar","family":"Das","sequence":"first","affiliation":[{"name":"Department of Medicine NYU Langone Medical Center  New York City New York USA"},{"name":"Division of Gastroenterology and Hepatology NYU Langone Medical Center  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Ho","sequence":"additional","affiliation":[{"name":"NYU Grossman School of Medicine  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jahnavi","family":"Udaikumar","sequence":"additional","affiliation":[{"name":"Department of Medicine NYU Langone Medical Center  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Chen","sequence":"additional","affiliation":[{"name":"NYU Grossman School of Medicine  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Delau","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology NYU Langone Medical Center  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aasma","family":"Shaukat","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology NYU Langone Medical Center  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology NYU Langone Medical Center  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raiya","family":"Sarwar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology NYU Langone Medical Center  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000152"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i6.659"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.08.013"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23294"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.04.009"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.112"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf02258391"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528709011139"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.14029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T03:25:59Z","timestamp":1725333959000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.14029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,28]]},"references-count":8,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/hepr.14029"],"URL":"https:\/\/doi.org\/10.1111\/hepr.14029","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,28]]},"assertion":[{"value":"2023-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}