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To date, no study has comprehensively assessed multiple renal function parameters in hospitalized patients with cirrhosis through a multiparametric analysis of renal biochemistry markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective, observational study including all consecutive patients hospitalized with cirrhosis who underwent a 43\u2010multiparametric renal function assessment between January 1, 2021, and June 30, 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients showed at least one of the following renal abnormalities: Kidney Disease: Improving Global Outcomes stage G2 or higher, sodium and\/or chloride excretion fraction &lt;1%, electrolyte\u2010free water clearance &lt;0.4\u00a0mL\/min, or tubular maximum phosphate reabsorption capacity &lt;0.8\u00a0mmol\/L. The estimated glomerular filtration rate equations significantly overestimated the measured creatinine clearance with median differences of +14\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> (95% CI 6\u201329) and +9\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> (95% CI 2\u201315) for European Kidney Function Consortium equations, respectively. Notably, 54% and 39% of patients demonstrated estimated glomerular filtration rates exceeding 30% of the measured creatinine clearance when the Chronic Kidney Disease \u2010 Epidemiology Collaboration and European Kidney Function Consortium formulas were employed, respectively. Substantial discrepancies in Kidney Disease: Improving Global Outcomes stage assignments were observed between the estimated glomerular filtration rate\u2010 and measured creatinine clearance\u2010based assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study underscores the value of a multiparametric renal function assessment as a routine tool for evaluating renal function in patients with cirrhosis. A high prevalence of medically actionable renal abnormalities spanning multiple renal function modules, including alterations in glomerular function, salt and solute\u2010free water excretion, and proximal tubule phosphate reabsorption, has been demonstrated in hospitalized patients with cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.14050","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T15:15:04Z","timestamp":1714058104000},"page":"1035-1048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multiparametric renal function assessment in cirrhotic patients shows high prevalence of medically actionable changes in multiple modules"],"prefix":"10.1111","volume":"54","author":[{"given":"Richard","family":"Belmonte","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine Division of Biochemistry, Molecular Biology, and Nutrition University Hospital of Nancy 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