{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T11:10:13Z","timestamp":1733569813394,"version":"3.30.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>An association between hepatitis B core\u2010related antigen (HBcrAg) kinetics and hepatocarcinogenesis during nucleoside (t)id analog (NA) treatment has recently been reported. HBcrAg kinetics and factors associated with HBcrAg response during tenofovir alafenamide (TAF) administration remain unclear. In this multicenter retrospective study, we aimed to clarify the efficacy and safety of TAF in treatment\u2010na\u00efve patients with chronic hepatitis B, focusing on the reduction in HBcrAg levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were treated with TAF monotherapy for 96\u00a0weeks, and the kinetics of HBcrAg during treatment and the factors associated with HBcrAg response (defined as a change in HBcrAg of \u22121\u00a0log\u00a0IU\/mL from baseline) were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population comprised 241 patients, 36.9% of whom were HBeAg\u2010positive. The median baseline HBcrAg level was 4.7\u00a0log\u00a0IU\/mL. The median change in HBcrAg from baseline was \u22121.1\u00a0log\u00a0IU\/mL at 96\u00a0weeks after treatment. The HBcrAg response rate at 96\u00a0weeks was 56.6% (43\/76). Multivariate analysis revealed high alanine transaminase level as an independent baseline factor associated with HBcrAg response at 96\u00a0weeks of treatment (<jats:italic>p<\/jats:italic>\u00a0=\u00a04.53\u00a0\u00d7\u00a010<jats:sup>\u22126<\/jats:sup>). No correlation was found between the HBcrAg and hepatitis B surface antigen kinetics in patients treated with TAF monotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In TAF monotherapy for patients with chronic hepatitis B, HBcrAg levels were significantly decreased and baseline alanine transaminase level is an important factor associated with HBcrAg reduction. As no correlation was found between HBcrAg and reduced hepatitis B surface antigen levels in this study, HBcrAg kinetics in addition to hepatitis B surface antigen may need to be monitored during TAF treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.14052","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T06:53:39Z","timestamp":1714460019000},"page":"993-1003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Kinetics of the hepatitis B core\u2010related antigen and treatment responses in chronic hepatitis B patients treated with tenofovir alafenamide"],"prefix":"10.1111","volume":"54","author":[{"given":"Norio","family":"Itokawa","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Division of Gastroenterology and Hepatology Nippon Medical School  Tokyo 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