{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:38:49Z","timestamp":1779370729418,"version":"3.53.0"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Esophagogastric varices (EGV) are a serious complication of hepatitis C virus (HCV)\u2010related liver cirrhosis (HCV\u2010LC). In most cases, portal hypertension improves after a sustained virologic response (SVR) is achieved with direct\u2010acting antiviral (DAA) treatment; however, in some cases, EGV exacerbation occurs after HCV elimination. We investigated whether von Willebrand factor (VWF) and a disintegrin\u2010like metalloproteinase with thrombospondin type\u20101 motif 13 (ADAMTS13) can predict EGV progression with HCV\u2010LC after SVR achievement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study enrolled 47 patients with HCV\u2010LC who achieved an SVR after DAA treatment. Eighteen patients experienced EGV progression after the SVR was achieved (EGV progression group). Twenty\u2010nine patients did not experience EGV progression after the SVR was achieved (non\u2010EGV progression group). Plasma VWF antigen levels and ADAMTS13 activity were measured the day before DAA treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The EGV progression group had significantly higher plasma VWF antigen levels (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.00331) and VWF\u2010to\u2010ADAMTS13 ratios (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.000249) than the non\u2010EGV progression group. Multivariate logistic regression models found that a VWF\u2010to\u2010ADAMTS13 ratio &gt;2.3 was the only risk factor for EGV progression after the SVR was achieved (hazard ratio [HR], 18.4; 95% confidence interval [CI], 3.08\u2013109; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.00138). During the observation period, patients with a VWF\u2010to\u2010ADAMTS13 ratio &gt;2.3 had a significantly higher cumulative incidence of EGV progression after SVR achievement than patients with a VWF\u2010to\u2010ADAMTS13 ratio \u22642.3 (HR, 6.4; 95% CI, 1.78\u201322.96; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0044).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The VWF\u2010to\u2010ADAMTS13 ratio before DAA treatment for HCV could predict EGV progression after SVR achievement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.14077","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T17:09:25Z","timestamp":1717607365000},"page":"1116-1127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ratio of von Willebrand factor to ADAMTS13 is a useful predictor of esophagogastric varices progression after sustained virologic response in patients with hepatitis C virus\u2010related liver cirrhosis"],"prefix":"10.1111","volume":"54","author":[{"given":"Satoshi","family":"Iwai","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6675-0475","authenticated-orcid":false,"given":"Takemi","family":"Akahane","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Takaya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nara Medical University  Kashihara 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