{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:37:37Z","timestamp":1770280657103,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Acute pancreatitis is a complication of acute liver failure (ALF). This study aimed to investigate the prevalence of and clinical features associated with acute pancreatitis in patients with ALF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed a cohort of ALF patients without hepatic encephalopathy diagnosed during a period 2011\u20132018, and compared clinical features between patients with acute pancreatitis and those without. Acute pancreatitis was diagnosed according to the Acute Pancreatitis Clinical Practice Guidelines 2021. A multivariate analysis was carried out to identify factors associated with acute pancreatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 83 ALF patients without hepatic encephalopathy (34 men; 11 deaths; 6 liver transplants; median age, 63\u00a0years). Acute pancreatitis occurred in nine patients (10.8%). The median time duration from ALF to the onset of acute pancreatitis was 8\u00a0days. The survival rate was lower in patients with than those without acute pancreatitis (22% vs. 86%). The model for end\u2010stage liver disease score (hazard ratio 1.10, 95% confidence interval 1.03\u20131.18) was found to be a significant factor associated with acute pancreatitis, whereas triglyceride, age, and sex were not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A high model for end\u2010stage liver disease score may be a marker to stratify patients with ALF at a risk of acute pancreatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.14083","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T10:24:50Z","timestamp":1718360690000},"page":"130-137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Low liver reserve is a risk factor for acute pancreatitis in patients with acute liver failure"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9627-138X","authenticated-orcid":false,"given":"Keisuke","family":"Kakisaka","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine School of Medicine Iwate Medical University  Iwate Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2496-2584","authenticated-orcid":false,"given":"Tokio","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine School of Medicine Iwate Medical University  Iwate Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ippeki","family":"Nakaya","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine School of Medicine Iwate Medical University  Iwate 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