{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:20Z","timestamp":1787014280973,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Refractory ascites from portal hypertension can be managed with regular large\u2010volume paracentesis (LVP) or transjugular intrahepatic portosystemic shunt (TIPS). Large\u2010volume paracentesis is clinically unsatisfactory and many patients are ineligible or relatively contraindicated for TIPS or Denver shunt. Proximal splenic artery embolization (PSAE) using coils or plugs reduces but does not completely stop splenic arterial inflow, differing from distal splenic artery embolization techniques. By reducing splenic arterial inflow, splenic vein outflow is also decreased, lowering portal pressure and thus treating refractory ascites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this institutional review board\u2010approved single\u2010center retrospective study, electronic medical records were reviewed to obtain demographics and baseline clinical and laboratory data, paracentesis data before and after PSAE, PSAE procedural details, and follow\u2010up imaging up to 12\u00a0months post\u2010PSAE. Mixed\u2010effects models were used for statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten patients with LVP\u2010dependent ascites meeting inclusion criteria underwent PSAE for refractory ascites from 2017 to 2024. Prior to PSAE, four patients had TIPS, three had liver transplants, and the remaining three were neither TIPS nor transplant candidates. In the month before PSAE, patients averaged 3.8\u00a0\u00b1\u00a01.7 paracentesis sessions, draining a total of 20.84\u00a0\u00b1\u00a010.39\u00a0L of fluid monthly. Post\u2010PSAE, the number of paracentesis sessions decreased to 2.1\u00a0\u00b1\u00a02.7, 1.0\u00a0\u00b1\u00a01.7, 0.4\u00a0\u00b1\u00a01.1, and 0.0\u00a0\u00b1\u00a00.0 at 1, 3, 6, and 12\u00a0months, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03). Corresponding ascitic volume drained decreased to 8.7\u00a0\u00b1\u00a010.3, 2.7\u00a0\u00b1\u00a06.4, 2.0\u00a0\u00b1\u00a05.4, and 0.0\u00a0\u00b1\u00a00.0\u00a0L (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01). Over the 12\u2010month follow\u2010up period, 6 of 10 patients became LVP\u2010independent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Proximal splenic artery embolization can improve refractory ascites in certain patients with portal hypertension, thus providing safe and effective treatment as an alternative to TIPS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.14116","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T11:08:27Z","timestamp":1727521707000},"page":"219-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Proximal splenic artery embolization for treatment of refractory ascites, a single\u2010center experience"],"prefix":"10.1111","volume":"55","author":[{"given":"Abdul Rehman","family":"Mustafa","sequence":"first","affiliation":[{"name":"Division of Interventional Radiology Department of Radiology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raneem","family":"Atta","sequence":"additional","affiliation":[{"name":"Division of Interventional Radiology Department of Radiology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"P. Goodman","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Interventional Radiology Department of Radiology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubin","family":"Irani","sequence":"additional","affiliation":[{"name":"Division of Interventional Radiology Department of Radiology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Zurkiya","sequence":"additional","affiliation":[{"name":"Division of Interventional Radiology Department of Radiology Massachusetts General Hospital  Boston Massachusetts 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