{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T20:43:27Z","timestamp":1772052207745,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The actual incidence of acute viral hepatitis in Japan remains unclear. We aimed to investigate trends in the incidence of acute hepatitis\u00a0B and C infections in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nationwide, multicenter, retrospective questionnaire\u2010based survey was conducted. Participating hospitals received questionnaires through nationwide geographically distributed regional core centers certified as specialists in hepatitis treatment. The questionnaire included hospital size and the number of patients diagnosed with acute hepatitis\u00a0B or C during each fiscal year (FY) from 2015 to 2022. The sex distribution in each FY was also documented. Comparisons were made before and during the COVID\u201019 era (2015\u20132019 vs. 2020\u20132022), and between populous and non\u2010populous prefectures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Responses to the questionnaires were obtained from 127 institutions in 29 prefectures covering eight regions in Japan. A median of 127.0 patients with acute hepatitis\u00a0B (interquartile range [IQR] 106.5\u2013131.8 patients) were reported during each FY, and the incidence significantly decreased during the fiscal years 2020\u20132022 compared with the fiscal years 2015\u20132020 (median 96.0 [IQR 91.0\u2013103.0] patients vs. 131.0 [IQR 128.0\u2013134.0] patients; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03). A median of 10.0 (IQR, 7.8\u201313.5) patients were reported with acute hepatitis\u00a0C during each FY. The proportions of men in acute hepatitis B and C were significantly higher in populous prefectures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Populous prefectures had a higher proportion of men among viral hepatitis patients than non\u2010populous prefectures. Estimating the high\u2010risk populations in each area could provide insights to advance the elimination of viral hepatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.14123","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T05:14:56Z","timestamp":1728623696000},"page":"301-308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Real\u2010world trends in acute viral hepatitis in Japan: A nationwide questionnaire\u2010based survey"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9584-043X","authenticated-orcid":false,"given":"Kazuya","family":"Okushin","sequence":"first","affiliation":[{"name":"Department of Infection Control and Prevention Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Gastroenterology Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Kanto","sequence":"additional","affiliation":[{"name":"Hepatitis Information Center The Research Center for Hepatitis and Immunology National Center for Global Health and Medicine  Ichikawa Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Korenaga","sequence":"additional","affiliation":[{"name":"Hepatitis Information Center The Research Center for Hepatitis and Immunology National Center for Global Health and Medicine  Ichikawa Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Ikeuchi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Kishida","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4477-6858","authenticated-orcid":false,"given":"Akira","family":"Kado","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeya","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of Infection Control and Prevention Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Infectious Diseases Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Takura","sequence":"additional","affiliation":[{"name":"Department of Healthcare Economics and Health Policy The University of Tokyo  Tokyo Japan"},{"name":"Department of Health Care Services Management Nihon University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yotsuyanagi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Advanced Clinical Research Center Institute of Medical Science The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Kind Nationwide Institution Group for Hepatitis Treatment in Japan (Knight\u2010Japan)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab401"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20101253(16)30107\u20108"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20101253(16)30024\u20103"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1402454"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1512614"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13417"},{"key":"e_1_2_10_8_1","unstructured":"National Institute of Infectious Diseases.IDWR surveillance data. Available from:https:\/\/www.niid.go.jp\/niid\/ja\/ydata\/11530\u2010report\u2010ja2021\u201030.html. Accessed 8 July 2024."},{"key":"e_1_2_10_9_1","unstructured":"National Institute of Infectious Diseases.IASR.44p33\u2013p34.2023. Available from:https:\/\/www.niid.go.jp\/niid\/ja\/hepatitis\u2010a\u2010m\/hepatitis\u2010a\u2010iasrtpc\/11891\u2010517t.html. Accessed 8 July 2024."},{"key":"e_1_2_10_10_1","unstructured":"National Institute of Infectious Diseases.IASR.42p1\u2013p2.2021. Available from:https:\/\/www.niid.go.jp\/niid\/ja\/hepatitis\u2010c\u2010m\/hepatitis\u2010c\u2010iasrtpc\/10125\u2010491t.html. Accessed 8 July 2024."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872\u2010034x.2010.00745.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010022\u201007152\u20105"},{"key":"e_1_2_10_13_1","unstructured":"National Center for Global Health and Medicine.The regional core centers. Available from:https:\/\/www.kanen.ncgm.go.jp\/en\/hosp.html. Accessed 7 July 2024."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13030"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.14123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T07:04:39Z","timestamp":1741763079000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.14123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,10]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/hepr.14123"],"URL":"https:\/\/doi.org\/10.1111\/hepr.14123","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,10]]},"assertion":[{"value":"2024-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}