{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:13:08Z","timestamp":1747185188071,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016289","name":"Taiju Life Social Welfare Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Steatotic liver disease, characterized by a combination of metabolic dysfunction, alcohol use, or specific etiologies, is a leading cause of chronic liver disease. However, the role of metabolic dysfunction in chronic liver disease with harmful alcohol use remains unclear. This study aimed to investigate factors associated with hepatic steatosis and fibrosis in patients with harmful alcohol use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Over a 2\u2010year period, we registered patients with harmful alcohol use, defined by an Alcohol Use Disorders Identification Test score of 8 or higher. We retrospectively analyzed background information, blood test results, ultrasound\u2010guided attenuation parameter (attenuation coefficient), and liver stiffness measurement. Hepatic steatosis was defined as attenuation coefficient \u22650.65\u00a0dB\/cm\/MHz, and fibrosis as liver stiffness measurement \u22657.5\u00a0kPa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 131 patients (82% men, median age 59\u00a0years). Linear regression analysis revealed significant associations with attenuation coefficient for body mass index \u226523 (0.08, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) and age (\u22120.002, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002). Liver stiffness measurement was associated with body mass index \u226523 (2.52, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), aspartate aminotransferase (0.02, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0189), gamma\u2010glutamyl transpeptidase (0.008, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), platelet count (\u22120.02, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), and prothrombin international normalized ratio (26.40, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Among the four groups classified by the presence or absence of steatosis and fibrosis, patients with fibrosis, but without steatosis, demonstrated the lowest liver reserve. In contrast, patients with both steatosis and fibrosis showed higher aspartate aminotransferase and gamma\u2010glutamyl transpeptidase levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Body mass index is associated with both hepatic steatosis and fibrosis in patients with harmful alcohol use.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.14128","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T03:55:06Z","timestamp":1729655706000},"page":"384-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Body mass index of 23 or greater is relevant to hepatic steatosis and fibrosis in patients with harmful alcohol use"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9627-138X","authenticated-orcid":false,"given":"Keisuke","family":"Kakisaka","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and 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