{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:33:05Z","timestamp":1790940785271,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22fk0310518"],"award-info":[{"award-number":["JP22fk0310518"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["23fk0310518h0002"],"award-info":[{"award-number":["23fk0310518h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Several studies have reported that chronic hepatitis B (CHB) patients with low hepatitis B surface antigen (HBsAg) levels (100 or 10\u00a0IU\/mL) at the cessation of nucleot(s)ide analogs (NA) have a favorable prognosis. In this retrospective study, we evaluated the duration of NA treatment and the factors associated with achieving these low HBsAg levels. We also examined the relationship between HBsAg and hepatitis B core\u2010related antigen (HBcrAg) levels at the time of NA discontinuation and subsequent clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 153 CHB patients who initiated NA therapy at our hospital, received treatment, and were followed up for over 1\u00a0year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cumulative incidence rates of achieving low HBsAg levels at 5 and 10\u00a0years post\u2010NA administration were as follows: 19.0% and 29.2% for HBsAg &lt;100\u00a0IU\/mL, 13.8% and 17.6% for HBsAg &lt;10\u00a0IU\/mL, and 9.5% and 13.5% for HBsAg &lt;0.05\u00a0IU\/mL, respectively. Hepatitis B virus genotypes other than genotype C (hazard ratio [HR] 3.47; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and an HBsAg level &lt;1000\u00a0IU\/mL at the start of NA therapy (HR 2.49; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008) were significantly associated with achieving HBsAg levels &lt;100\u00a0IU\/mL. Among 27 patients who discontinued NA therapy, 5 patients with HBsAg levels &lt;100\u00a0IU\/mL and HBcrAg levels &lt;3\u00a0log\u00a0U\/mL at the time of discontinuation did not experience virological relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The cumulative rates of achieving HBsAg levels &lt;100\u00a0IU\/mL were relatively high. Discontinuation of NA may be considered based on HBsAg and HBcrAg levels during the course of NA therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.14129","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T17:20:17Z","timestamp":1729963217000},"page":"309-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Factors associated with low hepatitis B surface antigen levels in chronic hepatitis B patients treated with nucleot(s)ide analogs"],"prefix":"10.1111","volume":"55","author":[{"given":"Takanori","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine Nagoya City University Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2473-6966","authenticated-orcid":false,"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Organization WH.Hepatitis B. 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