{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:29:57Z","timestamp":1767896997742,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Microvascular invasion (MVI) affects the prognosis and treatment of hepatocellular carcinoma (HCC); however, its preoperative diagnosis is challenging. Analysis of computed tomography (CT) images using radiomics can detect MVI, but its effectiveness depends on the imaging conditions. We compared the efficacies of radiomics, clinical, and combined models for predicting MVI in HCC using nonstandardized scanning protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter study included 533 patients who underwent hepatic resection for HCC. Patients were divided randomly into training (<jats:italic>n<\/jats:italic>\u00a0=\u00a0426) and test groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a0107). We manually extracted 3D CT features in hepatic arterial, portal venous, and venous phases. The radiomics model was trained by machine learning. A logistic regression model was developed based on clinical information, and a fused model was created integrating clinical information and radiomics prediction score (Rad_Score). We calculated areas under the receiver operating characteristic curves (AUCs) for the radiomics, clinical, and mixed models in the test groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The clinical model incorporated hepatitis B virus surface antigen, tumor diameter, and log\u2010transformed <jats:italic>\u03b1<\/jats:italic>\u2010fetoprotein and des\u2010gamma\u2010carboxyprothrombin. The AUCs of the radiomics and clinical models were comparable (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.76). Rad_Score was not an independent significant factor in the fused model (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.40) and its addition did not improve the accuracy of the clinical model alone (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.51).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A clinical model is as effective as a CT radiomics model for predicting MVI status in patients with HCC based on real\u2010world scanning data, and integration of both models does not improve the predictive performance compared with a clinical model alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.14149","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T06:11:42Z","timestamp":1734070302000},"page":"567-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real\u2010world efficacy of radiomics versus clinical predictors for microvascular invasion in patients with hepatocellular carcinoma: Large cohort study"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6690-4702","authenticated-orcid":false,"given":"Shotaro","family":"Kinoshita","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Nakaura","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Graduate School of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoharu","family":"Yoshizumi","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0382-2520","authenticated-orcid":false,"given":"Shinji","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Ide","sequence":"additional","affiliation":[{"name":"Department of Surgery Saga University Faculty of Medicine  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Noshiro","sequence":"additional","affiliation":[{"name":"Department of Surgery Saga University Faculty of Medicine  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Surgery NHO Nagasaki Medical Center  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamotsu","family":"Kuroki","sequence":"additional","affiliation":[{"name":"Department of Surgery NHO Nagasaki Medical Center  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Takami","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery Clinical Research Institute NHO Kyushu Medical Center  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2828-0951","authenticated-orcid":false,"given":"Hiroaki","family":"Nagano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Breast and Endocrine Surgery Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3246-557X","authenticated-orcid":false,"given":"Atsushi","family":"Nanashima","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreas Surgery Department of Surgery University of Miyazaki Faculty of Medicine  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Utsunomiya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Oita Prefectural Hospital  Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Kajiwara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Surgery Saga\u2010Ken Medical Centre Koseikan  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Sakoda","sequence":"additional","affiliation":[{"name":"Department of Surgery Kagoshima Kouseiren Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohji","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Surgery Gastroenterology and Hepatology Center Kitakyushu City Yahata Hospital  Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9046-0454","authenticated-orcid":false,"given":"Toru","family":"Beppu","sequence":"additional","affiliation":[{"name":"Department of Surgery Yamaga City Medical Center  Yamaga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhisa","family":"Takatsuki","sequence":"additional","affiliation":[{"name":"Department of Digestive and General Surgery Graduate School of Medicine University of the Ryukyus  Nishihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Noritomi","sequence":"additional","affiliation":[{"name":"Department of Surgery Fukuoka Tokushukai Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7876-0152","authenticated-orcid":false,"given":"Susumu","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Department of Surgery Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010018\u20100073\u20104"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21966"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.12.037"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534\u2010007\u20101288\u20104"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015151169"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.819670"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.02.023"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinsp.2023.100264"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.12123"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019190928"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018172361"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.222729"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(14)71116\u20107"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx034"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-79161-2_10"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488035"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2020.100875"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010017\u20103293\u20106"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2015.4257"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201093528\u20107"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605\u2010019\u201004140\u20100"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.005"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2021.733343"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.04.125"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/83.4.875"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2018.09.017"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2018.10.018"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S216178"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.745085"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.14149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T19:01:58Z","timestamp":1743793318000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.14149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/hepr.14149"],"URL":"https:\/\/doi.org\/10.1111\/hepr.14149","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,12]]},"assertion":[{"value":"2024-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}