{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:03:13Z","timestamp":1789833793570,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Acute alcoholic hepatitis (AAH) can be fatal, particularly when it progresses to severe alcoholic hepatitis. There are several prognostic markers, but none specifically reflects liver regenerative capacity. This study investigated the serum alpha\u2010fetoprotein (AFP)\/hepatocyte growth factor (HGF) ratio as a novel prognostic indicator for AAH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center retrospective analysis was conducted on 20 AAH patients, including 12 with severe alcoholic hepatitis, hospitalized between April 2007 and September 2023. Serum AFP and HGF levels were measured at diagnosis, and the AFP\/HGF ratio was calculated. Prognostic performance was assessed using receiver operating characteristic analysis, Kaplan\u2013Meier survival analysis, and a validation cohort of 67 non\u2010alcohol\u2010related liver failure cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Receiver operating characteristic analysis demonstrated excellent prognostic performance for the AFP\/HGF ratio, with an area under the curve of 0.97. Patients with high AFP\/HGF ratios (\u22651.86) had significantly longer overall survival than those with low ratios (&lt;1.86; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). The median survival time for the low\u2010ratio group was 55\u00a0days. In severe alcoholic hepatitis patients, a high AFP\/HGF ratio was also associated with significantly longer overall survival (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.013). At diagnosis, surviving patients had significantly higher AFP\/HGF ratios when compared with subsequently deceased patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005). In the non\u2010AAH cohort, no significant difference was observed between groups, but survivors showed a trend toward higher AFP\/HGF ratios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The AFP\/HGF ratio is a novel and highly specific prognostic marker for AAH, reflecting liver regenerative capacity. It may guide early therapeutic decisions and improve outcomes, particularly for high\u2010risk AAH patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.14174","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T15:44:11Z","timestamp":1739979851000},"page":"922-931","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum alpha\u2010fetoprotein\/hepatocyte growth factor ratio as a novel biomarker predicting the prognosis of acute alcoholic hepatitis"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3456-6921","authenticated-orcid":false,"given":"Hiroki","family":"Inada","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Faculty of Life Sciences Kumamoto University  Kumamoto 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