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In this study, we investigated the association between serum interleukin\u20106 and acute phase reactant levels and the disease stage and prognosis of patients with liver cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center retrospective cohort of 359 patients with liver cirrhosis was staged according to the symptomatic decompensation. Baseline serum C\u2010reactive protein , interleukin\u20106, procalcitonin, and serum amyloid A protein levels were measured. The outcomes of further decompensation, hepatocellular carcinoma development, and mortality were identified during a 3.3\u2010year median follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum C\u2010reactive protein , interleukin\u20106, and procalcitonin levels were significantly different across the stages. The multivariate Cox proportional hazards model identified serum interleukin\u20106 as an independent predictor of further decompensation in patients with compensated and the first single decompensated cirrhosis. Kaplan\u2013Meier analyses showed that the probability of further decompensation was stratified by serum interleukin\u20106 level in a dose\u2010dependent manner. In the entire cohort, serum interleukin\u20106 level also showed a significant association with liver\u2010related and all\u2010cause mortalities, but not with hepatocellular carcinoma development, independent of stage and liver disease severity indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elevated levels of serum markers of systemic inflammation were associated with symptomatic decompensation, and serum interleukin\u20106 level is a predictor of further decompensation and mortality in patients with liver cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.14175","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T09:24:42Z","timestamp":1739352282000},"page":"696-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Serum pro\u2010inflammatory cytokine interleukin\u20106 level is predictive of further decompensation and mortality in liver cirrhosis"],"prefix":"10.1111","volume":"55","author":[{"given":"Yuji","family":"Ikeda","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Nago","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rihwa","family":"Om","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Terai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayato","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-7283","authenticated-orcid":false,"given":"Shunsuke","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Nagahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0006-8948","authenticated-orcid":false,"given":"Takuya","family":"Genda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(12)61728\u20100"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(24)00685\u20108"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324525"},{"key":"e_1_2_11_5_1","unstructured":"Ministry of Health Labour and Welfare.Annual Health labour and Welfare report 2021.https:\/\/www.mhlw.go.jp\/english\/wp\/wp\u2010hw14\/dl\/01e.pdf. 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