{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:41:50Z","timestamp":1785519710171,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to assess the prognostic significance of hand grip strength (HGS) and skeletal muscle mass index (SMI) in patients with alcohol\u2010related cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>535 patients with liver cirrhosis (LC) were assessed for HGS and computed tomography (CT)\u2010based SMI. They were categorized into alcohol\u2010related liver disease (ARLD; <jats:italic>n<\/jats:italic>\u00a0=\u00a0226), metabolic dysfunction\u2010associated steatohepatitis (MASH; <jats:italic>n<\/jats:italic>\u00a0=\u00a0119), and virus\u2010related cirrhosis (VC, <jats:italic>n<\/jats:italic>\u00a0=\u00a0190) groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall prevalence of sarcopenia was 16.4%, 11.8%, and 27.4% in the ARLD, MASH, and VC groups, respectively. Three factors including low SMI, low albumin (Alb) levels, low sodium (Na) levels, and two factors including low HGS and low Alb levels, and three factors including the presence of ascites, low cholinesterase (Ch\u2010E) levels, and low HGS were identified as prognostic factors for mortality in the ARLD, MASH and VC groups, respectively. In the ARLD group, overall survival (OS) was significantly lower in low SMI\u00a0+\u00a0low HGS and normal HGS\u00a0+\u00a0low SMI (pre\u2010sarcopenia) than in normal SMI and HGS. OS was significantly lower in sarcopenia than in normal SMI\u00a0+\u00a0low HGS (dynapenia). In the MASH group, OS was significantly lower in sarcopenia and dynapenia than in normal SMI and HGS. In the VC group, OS was significantly lower in sarcopenia and dynapenia than in normal SMI and HGS; OS was significantly lower in sarcopenia than in pre\u2010sarcopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the ARLD group, SMI could serve as a more powerful predictor of survival than HGS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.14186","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T04:55:50Z","timestamp":1743051350000},"page":"868-882","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prognostic significance of skeletal muscle mass in patients with alcohol\u2010related cirrhosis"],"prefix":"10.1111","volume":"55","author":[{"given":"Akihiko","family":"Shibamoto","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Nara Medical University  Nara 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