{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:44:12Z","timestamp":1787312652422,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Noninvasive detection of liver steatosis and monitoring its progression are essential for effective therapeutic management. We validated the diagnostic performance of an ultrasonography (US)\u2010based steatotic liver scoring system, derived from the B\u2010mode method and the hepatic steatosis index (HSI) for the detection of liver steatosis, as identified by proton density fat fraction (PDFF) measurements on magnetic resonance imaging (MRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 916 patients with chronic liver disease were included in the analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median MRI\u2010PDFF value was 4.0% (interquartile range: 2.0\u20139.7). The distribution of scores (0\/1\/2\/3\/4\/5\/6) according to the US\u2010based steatotic liver scoring system was as follows: 475, 36, 99, 78, 141, 66, and 21, respectively. The median HSI was 32.8 (28.9\u201337.4). A significant positive association between advancing scores of the US\u2010based steatotic liver scoring system and increasing MRI\u2010PDFF values was observed (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The diagnostic performance of the US\u2010based steatotic liver scoring system and HSI for detecting steatosis grades \u22651, \u22652, and 3, as determined by MRI\u2010PDFF, showed areas under the receiver operating characteristic curve of 0.940 and 0.842 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), 0.949 and 0.847 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and 0.945 and 0.864 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), respectively. When the cutoff values of the scoring system were set at 2, 3, and 4 for steatosis grades \u22651, \u22652, and 3, the sensitivity and specificity were 90.6% and 90.5%, 92.9% and 83.0%, and 93.3% and 84.0%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The B\u2010mode US\u2010based steatotic liver scoring system demonstrated robust diagnostic capability in detecting liver steatosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.14190","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T14:03:11Z","timestamp":1743343391000},"page":"818-829","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Validation of a B\u2010mode ultrasonography scoring system for assessing liver steatosis: A comparison with MRI\u2010Derived proton density fat fraction"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0976-6761","authenticated-orcid":false,"given":"Toshifumi","family":"Tada","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-495X","authenticated-orcid":false,"given":"Takashi","family":"Kumada","sequence":"additional","affiliation":[{"name":"Gifu Kyoritsu University  Ogaki Japan"},{"name":"Institute of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Gotoh","sequence":"additional","affiliation":[{"name":"Department of Imaging Diagnosis Ogaki Municipal Hospital  Ogaki 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