{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:32:53Z","timestamp":1790947973767,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>Sj\u00f6gren's syndrome is a common comorbidity in patients with primary biliary cholangitis (PBC). Anti\u2010Ro52 autoantibodies against the protein TRIM21 are often seen in Sj\u00f6gren's syndrome. TRIM21 consists of four domains (PRY\/SPRY, Coiled\u2010Coil, B\u2010box, and RING domain), each with a specific function. We hypothesized that patients with PBC and concomitant autoantibodies against TRIM21 had a higher risk of developing Sj\u00f6gren's syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using ELISA, we analyzed plasma from 236 Danish patients with PBC. Binomial regression assessed the risk rates between demographics, serologic variables, PBC\u201040 results, and autoantibody positivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty patients (16.9%) tested positive for anti\u2010Ro52 autoantibodies, with 23 (9.7%) samples positive against Coiled\u2010Coil, 12 against PRY\/SPRY (5.1%), and 10 against RING (4.2%). Increased IgG plasma levels, reports of <jats:italic>dry mouth<\/jats:italic>, and a diagnosis of Sj\u00f6gren's syndrome increased the risk of both anti\u2010Ro52 and all domain autoantibodies. In the anti\u2010Ro52 positive subgroup, no less than 14 undiagnosed patients met the criteria for Sj\u00f6gren's syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We observed a 16.9% positivity of anti\u2010Ro52 autoantibodies and an association between having these autoantibodies and elevated IgG, the symptom <jats:italic>dry mouth,<\/jats:italic> and having Sj\u00f6gren's syndrome. Furthermore, we found a sizable undiagnosed group of Sj\u00f6gren's patients in the anti\u2010Ro52 positive subgroup. Our results suggest that Sj\u00f6gren's patients are underdiagnosed in patients with PBC. We propose that patients with PBC be tested for anti\u2010Ro52 autoantibodies and, if positive, referred for rheumatological examination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.14213","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T09:49:54Z","timestamp":1748252994000},"page":"1128-1138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti\u2010Ro52\/TRIM21 autoantibodies predict Sj\u00f6gren's syndrome in patients with primary biliary cholangitis"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2138-2477","authenticated-orcid":false,"given":"Marie Louise N\u00e6stholt","family":"Dahl","sequence":"first","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"},{"name":"Department of Rheumatology Aarhus University Hospital  Aarhus 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