{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:14:26Z","timestamp":1783116866304,"version":"3.54.6"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:00:00Z","timestamp":1751673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to clarify the impact of tirzepatide as a treatment for Type 2 diabetes mellitus (T2DM) in patients with metabolic dysfunction\u2010associated steatotic liver disease (MASLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010arm, prospective, observational pilot study included 16 patients with MASLD and T2DM who were treated with tirzepatide. Of these, 13 patients completed 48\u00a0weeks of treatment. Tirzepatide was initiated at a dose of 2.5\u00a0mg once weekly for 4\u00a0weeks, and dose adjustments were left to the discretion of the attending physician based on efficacy and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant improvements in body weight, liver enzymes, and hemoglobin A1c were found at Week 12 and were sustained throughout the 48\u2010week treatment period compared with baseline values (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Controlled attenuation parameter significantly decreased from baseline to 48\u00a0weeks (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Changes in body weight were correlated with changes in alanine aminotransferase levels (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.57, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) but not with changes in controlled attenuation parameter (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.45, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.12). The results of noninvasive tests for fibrosis, including Type IV collagen 7s, <jats:italic>Wisteria floribunda<\/jats:italic> agglutinin\u2010positive Mac\u20102\u2010binding protein, the fibrosis\u20104 index, and the liver stiffness measurement, significantly decreased from baseline to 48\u00a0weeks (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Most adverse events were transient Grades 1\u20132 gastrointestinal symptoms, including nausea (5 patients, 31.3%), diarrhea (3 patients, 18.8%), and constipation (2 patients, 12.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tirzepatide treatment for T2DM in patients with MASLD significantly improved liver steatosis and injury, surrogate markers of liver fibrosis, and diabetes status, and reduced body weight.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.14241","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T04:20:31Z","timestamp":1751689231000},"page":"1346-1352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Tirzepatide Treatment on Hepatic Biomarkers in Patients With Metabolic Dysfunction\u2010Associated Steatotic Liver Disease and Type 2 Diabetes Mellitus"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5817-1845","authenticated-orcid":false,"given":"Taeang","family":"Arai","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3374-7111","authenticated-orcid":false,"given":"Masanori","family":"Atsukawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Nagao","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zento","family":"Yamada","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon 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