{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:10:31Z","timestamp":1781827831534,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24fk0210125"],"award-info":[{"award-number":["JP24fk0210125"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Primary biliary cholangitis (PBC) is a chronic, slowly progressive, and autoimmune liver disease. This study aimed to establish the clinicopathological features that accurately predict long\u2010term prognosis in patients with early\u2010stage PBC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present long\u2010term (8.8\u00a0years), multicenter, and retrospective investigation enrolled 274 treatment\u2010na\u00efve PBC patients who had undergone liver biopsy. Among them, 207 patients with albumin\u2013bilirubin (ALBI) grade 1 were categorized as clinical early\u2010stage, and 230 patients with Nakanuma stage 1\/2 were classified as pathological early\u2010stage. The prognostic factors related to the time to liver\u2010related events (LRE) were statistically evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cox regression analysis identified Nakanuma bile duct loss score of \u2265\u00a01 as a significant independent factor associated with LRE development in clinical early\u2010stage PBC patients (hazard ratio [HR] 12.89, 95% confidence interval [95% CI] 1.60\u2013103.96,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.016). Kaplan\u2013Meier testing revealed that the cumulative incidence of LRE was significantly higher in patients with bile duct loss score of \u2265\u00a01 than in those with bile duct loss score 0 (log\u2010rank test;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Similarly, bile duct loss score could predict LRE in pathological early\u2010stage PBC patients, as confirmed by both multivariable Cox regression (HR 6.60, 95% CI 1.37\u201331.86,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.019) and Kaplan\u2013Meier (log\u2010rank test;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nakanuma bile duct loss score may be a valuable prognostic indicator in the early clinical and pathological stages of PBC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.70018","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T04:31:13Z","timestamp":1755664273000},"page":"1621-1630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Significance of Bile Duct Loss in Early\u2010Stage Primary Biliary Cholangitis: A Long\u2010Term Observational Study"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5715-1748","authenticated-orcid":false,"given":"Taiki","family":"Okumura","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1481-1029","authenticated-orcid":false,"given":"Takefumi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of 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