{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:20:05Z","timestamp":1789676405577,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Biliary tract cancers, including intrahepatic cholangiocarcinoma (ICC), are aggressive with limited treatment options and poor prognosis. Recent trials (TOPAZ\u20101, Keynote\u2010966) showed improved survival with ICIs plus gemcitabine and cisplatin. Targeted therapies, including FGFR inhibitors, are promising for cholangiocarcinoma patients with\n                      <jats:italic>FGFR<\/jats:italic>\n                      2 gene fusions or rearrangements, although few reports exist on\n                      <jats:italic>FGFR<\/jats:italic>\n                      2 positivity and clinical data in Asia. This study aims to address this gap by evaluating\n                      <jats:italic>FGFR<\/jats:italic>\n                      2 fusions or rearrangements in intrahepatic and perihilar cholangiocarcinoma patients across Asia, providing insights into their clinical significance and potential therapeutic implications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This multicenter study evaluated the frequency of\n                      <jats:italic>FGFR<\/jats:italic>\n                      2 rearrangements and fusion genes in ICC and perihilar cholangiocarcinoma across Asia (Thailand, Malaysia, Vietnam, and Taiwan) using fluorescence in situ hybridization (FISH) and comprehensive genomic profiling with the Todai OncoPanel2 (TOP2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 113 patients, 102 were eligible;\n                      <jats:italic>FGFR2<\/jats:italic>\n                      rearrangements\/fusions were found in 3.9% (4 cases) by FISH, all of which were also confirmed by the TOP2 panel, consistent with the Japanese PRELUDE study. Younger age was significantly associated with\n                      <jats:italic>FGFR<\/jats:italic>\n                      2 positivity (34.5\u00a0\u00b1\u00a03.17 vs. 62.69\u00a0\u00b1\u00a01.04;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0003), whereas no correlation was observed with hepatitis infection, alcohol use, or smoking history. Genomic profiling identified frequent mutations in\n                      <jats:italic>TP<\/jats:italic>\n                      53,\n                      <jats:italic>KRAS<\/jats:italic>\n                      , and\n                      <jats:italic>ARID1A<\/jats:italic>\n                      with notable regional variability. Patients treated with ICIs showed significantly longer progression\u2010free survival compared to other therapies: ICI + cytotoxic (348\u00a0days, 95% CI: 0\u2013897), platinum\u2010based + GEM (240\u00a0days, 95% CI: 197\u2013282), and other treatments (168\u00a0days, 95% CI: 11\u2013325;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.017).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>FGFR<\/jats:italic>\n                      2 positivity rate in Asia is slightly lower but consistent with Japanese reports and is more common in younger patients with ICC. Distinct genetic alterations may characterize Asian populations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.70031","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T05:16:35Z","timestamp":1758086195000},"page":"78-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>FGFR2<\/i>\n                    Fusions or Rearrangements in Young Intrahepatic and Perihilar Cholangiocarcinoma Patients: Key Genetic Insights From a Pan\u2010Asian Study"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5045-8082","authenticated-orcid":false,"given":"Yuta","family":"Maruki","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital  Tokyo Japan"},{"name":"Molecular Oncology The Jikei University Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1788-559X","authenticated-orcid":false,"given":"Yasushi","family":"Yatabe","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiharu","family":"Mizoguchi","sequence":"additional","affiliation":[{"name":"Department of International Clinical Development National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen Yasmin","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Department of International Clinical Development National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aumkhae","family":"Sookprasert","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Khon Kaen University by Faculty of Medicine  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charuwan","family":"Akewanlop","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Huang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology Taipei Veterans General Hospital  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaphop","family":"Sirachainan","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao Van","family":"Tu","sequence":"additional","affiliation":[{"name":"Cancer Research and Clinical Trials Center National Cancer Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozita Abdul","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaiyut","family":"Charoentum","sequence":"additional","affiliation":[{"name":"Oncology Unit Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwoei Fen Soo","family":"Hoo","sequence":"additional","affiliation":[{"name":"Department of Oncology Radiotherapy and Palliative Care Penang General Hospital  George Town Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhana","family":"Yusak","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy &amp; Oncology National Cancer Institute  Putrajaya Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rangasamy","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Oncology &amp; Radiotherapy Department Hospital Sultan Ismail  Johor Bahru Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrapim","family":"Sunpaweravong","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Prince of Songkla University Hospital  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei Jye","family":"Voon","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Oncology and Palliative Care Hospital Umum Sarawak (Sarawak General Hospital)  Kuching Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najihah Abu","family":"Bakar","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology Hospital Kuala Lumpur  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junki","family":"Mizusawa","sequence":"additional","affiliation":[{"name":"Japan Clinical Oncology Group Data Center\/Operations Office National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi Sumiyoshi","family":"Okuma","sequence":"additional","affiliation":[{"name":"Department of International Clinical Development National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3534-8296","authenticated-orcid":false,"given":"Kenichi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of International Clinical Development National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chigusa","family":"Morizane","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Okusaka","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1432603"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2200015"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)00727\u20104"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(21)00027\u20109"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2024.103647"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.11.030"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(20)30109\u20101"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206834"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26890"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010020\u201001735\u20102"},{"key":"e_1_2_10_12_1","first-page":"224","article-title":"WHO Classification of Tumours Editorial Board. 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