{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:11:21Z","timestamp":1791515481104,"version":"4.3.4"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Hepatitis C virus (HCV) infection remains a global health concern. Although the World Health Organization (WHO) proposed a strategy to eliminate HCV by 2030, Japan faces challenges owing to limited access and insufficient support for high\u2010risk populations. Previously, HCV diagnoses required a two\u2010step process, delaying results and increasing costs. In 2024, Japan introduced the Elecsys HCV Duo immunoassay, which enables the qualitative dual detection of HCV core antigen (HCV Ag) and antibodies against HCV (anti\u2010HCV). This study aimed to evaluate its effectiveness in identifying patients with an active HCV infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on 13,045 patients who underwent HCV screening using the Elecsys HCV Duo immunoassay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of these, 244 were positive for HCV Duo. All 14 patients who were positive for HCV Ag and anti\u2010HCV had active infection, as confirmed by HCV\u2010RNA testing. Five HCV Ag\u2010positive but anti\u2010HCV\u2010negative patients were identified as false positives. In contrast, five anti\u2010HCV\u2010positive but HCV Ag\u2010negative patients had active infections with detectable HCV\u2010RNA. A low viral load and possible antibody interference were identified as potential reasons for false\u2010negative HCV Ag results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The Elecsys HCV Duo immunoassay effectively simplified HCV diagnosis and facilitated early detection and treatment initiation. Although false\u2010negative HCV Ag results occurred, the assay ensured linkage to care for patients with both HCV Ag and anti\u2010HCV positivity. These advancements may contribute to enhanced HCV care and support national elimination efforts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.70037","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T12:39:55Z","timestamp":1757507995000},"page":"125-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Evaluation of Initial Experiences With the Qualitative Dual Detection of Core Antigen and Antibodies Immunoassay for Hepatitis C Virus Screening Test"],"prefix":"10.1111","volume":"56","author":[{"given":"Rihwa","family":"Om","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-7283","authenticated-orcid":false,"given":"Shunsuke","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Kondo","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Ashikawa","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Nago","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Terai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayato","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Kodama","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0006-8948","authenticated-orcid":false,"given":"Takuya","family":"Genda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital  Izunokuni Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"WHOHepatitis C (updated on 2024 April 9) accessed June 23 2025 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/hepatitis\u2010c."},{"key":"e_1_2_11_3_1","unstructured":"WHOGlobal Health Sector Strategy on Viral Hepatitis 2016\u20102021. Towards Ending Viral Hepatitis (updated on 2016 May 17) accessed June 23 2025 https:\/\/iris.who.int\/bitstream\/handle\/10665\/246177\/WHO\u2010HIV\u20102016.06\u2010eng.pdf."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20101253(23)00408\u20109"},{"key":"e_1_2_11_5_1","unstructured":"CDA Foundation\u2019s Polaris Observation accessed June 23 2025 https:\/\/cdafound.org\/polaris."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2022.105293"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14192179"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.00832\u201024"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.jjid.2025.032"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0313771"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.70037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hepr.70037","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.70037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T09:08:33Z","timestamp":1779527313000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.70037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,10]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/hepr.70037"],"URL":"https:\/\/doi.org\/10.1111\/hepr.70037","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,10]]},"assertion":[{"value":"2025-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}