{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:38:14Z","timestamp":1770136694737,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Direct oral anticoagulants (DOACs) are increasingly used in various thrombotic disorders. However, data on the use of DOACs in patients with Budd\u2013Chiari syndrome (BCS) remain limited. We aimed to assess the efficacy and safety of DOACs in patients with BCS after percutaneous recanalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We carried out a single\u2010center retrospective analysis of patients with primary BCS who received DOACs or vitamin K antagonists (VKAs) after percutaneous recanalization. The primary endpoints were the cumulative primary and secondary patency rates. Secondary endpoints included bleeding events and death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 236 patients were included, with 133 receiving DOACs (rivaroxaban,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a059; dabigatran,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a074) and 103 receiving VKAs. The median duration of anticoagulation was 18.8\u00a0months (IQR: 6.3\u201328.6) in the DOAC group (median follow\u2010up: 22.8\u00a0months, IQR: 12.6\u201331.8) and 32.2\u00a0months (IQR: 6.0\u201373.5) in the VKA group (median follow\u2010up: 70.6\u00a0months, IQR: 39.0\u201385.6). The 1\u2010, 2\u2010, and 3\u2010year cumulative primary patency rates were 79.3%, 70.0%, and 62.9% in the DOAC group, compared to 83.5%, 78.2%, and 73.8% in the VKA group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.269). Furthermore, no significant differences were observed between the DOAC and VKA groups in major bleeding rates (DOAC: 1.8 per 100 person\u2010years; VKA: 2.8 per 100 person\u2010years; incidence rate ratio [IRR]: 1.6, 95% CI: 0.4\u20135.9;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.436).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DOACs may be an effective and safe alternative to VKAs for patients with BCS after percutaneous recanalization. Further prospective studies are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.70057","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:29:39Z","timestamp":1760635779000},"page":"195-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Direct Oral Anticoagulants in Budd\u2013Chiari Syndrome After Percutaneous Recanalization"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7849-5521","authenticated-orcid":false,"given":"Chengjian","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Sichuan University\u2010University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Sichuan University\u2010University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyan","family":"Gao","sequence":"additional","affiliation":[{"name":"West China School of Medicine Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoze","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Sichuan University\u2010University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2835-9547","authenticated-orcid":false,"given":"Guofeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Sichuan University\u2010University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3992-5866","authenticated-orcid":false,"given":"Xuefeng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Sichuan University\u2010University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.07.040"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31646"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2207738"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.12.022"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12120856"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.02.015"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072\u2010021\u201010189\u20104"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010024\u201000998\u2010x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2019.02.006"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14843"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.04.024"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.14363"},{"key":"e_1_2_10_14_1","first-page":"e44S","volume-title":"American College of Chest Physicians Evidence\u2010Based Clinical Practice Guidelines. 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