{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:15:23Z","timestamp":1785795323206,"version":"3.56.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Most existing evidence regarding liver transplantation (LT) for autoimmune hepatitis (AIH) originates from European cohorts, hindering the applicability of current guidelines to other populations because of possible geographic variations. There is an urgent need for region\u2010specific prognostic models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed 164 AIH patients from Brazil and Venezuela undergoing LT between 2002 and 2025, the largest AIH LT cohort from Latin America to date. Random survival forests (RSF) identified key predictors of overall survival (OS), graft survival (GS), and AIH recurrence (rAIH). Clustering based on predicted risks identified high\u2010risk groups with significantly worse outcomes (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001 for all). Penalized models with the most important variables from the RSF assessed risk stratification.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>5\u2010, 10\u2010, and 20\u2010year OS were 83%, 78%, and 49%. rAIH rates increased from 6% at 5\u00a0years to 34% at 20\u00a0years. Mycophenolate sodium use in maintenance therapy was ranked as the most important factor for OS (Hazard ratio [HR]\u00a0=\u00a00.44) and GS (HR\u00a0=\u00a00.46) prediction, while younger age was the most important risk factor for rAIH. LASSO models accurately predicted early outcomes (1\u2010year AUCs: OS 0.73, GS 0.73, rAIH 0.81). In a landmark analysis (6\u00a0months post\u2010LT), infectious complications emerged as the main determinant for long\u2010term OS, and a new model improved 5\u2010 and 10\u2010year OS prediction (AUCs: 0.76 and 0.79, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This analysis identifies key predictors that define high\u2010risk clusters for early and long\u2010term outcomes in Latin American AIH patients post\u2010LT, highlighting potential region\u2010specific factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.70069","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T06:00:14Z","timestamp":1764396014000},"page":"339-350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Autoimmune Hepatitis Profiles After Liver Transplantation in Latin American Patients: A Cluster Analysis of Clinical Outcomes"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9049-0996","authenticated-orcid":false,"given":"Pedro Robson","family":"Costa Passos","sequence":"first","affiliation":[{"name":"Faculty of Medicine Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2947-1498","authenticated-orcid":false,"given":"Isabel","family":"Bastos de Medeiros","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8461-8814","authenticated-orcid":false,"given":"Tiago Franco","family":"David","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Federal University of Cear\u00e1  Fortaleza 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Feitosa","family":"Neto","sequence":"additional","affiliation":[{"name":"Liver Transplant Service Walter Cant\u00eddio University Hospital Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7762-7149","authenticated-orcid":false,"given":"Cl\u00e9bia","family":"Azevedo de Lima","sequence":"additional","affiliation":[{"name":"Liver Transplant Service Walter Cant\u00eddio University Hospital Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6608-3134","authenticated-orcid":false,"suffix":"J\u00fanior","given":"Ant\u00f4nio Brazil","family":"Viana","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Walter Cant\u00eddio University Hospital Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Vieira","family":"Motta","sequence":"additional","affiliation":[{"name":"Translational Gastroenterology and Liver Unit University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia Melo","family":"Carone Linhares","sequence":"additional","affiliation":[{"name":"Liver Transplant Service Walter Cant\u00eddio University Hospital Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6622-6585","authenticated-orcid":false,"given":"Elodie Bomfim","family":"Hyppolito","sequence":"additional","affiliation":[{"name":"Liver Transplant Service Walter Cant\u00eddio University Hospital Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0845-2864","authenticated-orcid":false,"given":"Gustavo Rego","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department 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