{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T12:44:19Z","timestamp":1775133859300,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2013associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease, yet its underlying mechanisms remain incompletely understood. Beyond hemostasis, platelets actively participate in inflammation, fibrosis, and vascular remodeling. This study investigated platelet proteomic alterations across MASLD stages to explore their potential contribution to disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 25 MASLD patients undergoing hepatic catheterization and 21 viral\u2010hepatitis controls. Platelets were isolated from sinusoidal and peripheral blood and profiled using high\u2010throughput, mass spectrometry\u2013based proteomics. Differential\u2010abundance and pathway analyses were performed with appropriate statistical correction and exploratory evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1052 platelet proteins were identified. Several proteins showed large effect sizes and are reported as putative markers: histidine\u2010rich glycoprotein and ADP\u2010ribosylation factor\u2010like protein 8B were less abundant in MASLD than in controls. In advanced disease, perforin\u20101 and macro\u2010H2A1 were increased in sinusoidal blood, suggesting immune activation and endothelial injury. Docking protein 1 and TGF\u2010\u03b2\u2013induced protein IG\u2010H3 were enriched in patients with perisinusoidal fibrosis and obliterative venopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Putative platelet\u2010derived proteins associated with immune regulation, vascular remodeling, and metabolic dysfunction were identified in MASLD. These exploratory findings will be validated in a prospective, metabolically matched cohort to confirm disease specificity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.70090","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:45:03Z","timestamp":1765043103000},"page":"446-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Platelet Proteomics: A Glimpse Into Metabolic Dysfunction\u2010Associated Steatotic Liver Disease Pathogenesis"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1261-650X","authenticated-orcid":false,"given":"Iulia","family":"Minciuna","sequence":"first","affiliation":[{"name":"Regional Institute of Gastroenterology and Hepatology \u201cProf. Dr. Octavian Fodor\u201d  Cluj\u2010Napoca Romania"},{"name":"University of Medicine and Pharmacy \u201cIuliu Ha\u0163ieganu\u201d  Cluj\u2010Napoca 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Institute of Gastroenterology and Hepatology \u201cProf. Dr. Octavian Fodor\u201d  Cluj\u2010Napoca Romania"},{"name":"University of Medicine and Pharmacy \u201cIuliu Ha\u0163ieganu\u201d  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3605-8007","authenticated-orcid":false,"given":"Petra","family":"Fischer","sequence":"additional","affiliation":[{"name":"Regional Institute of Gastroenterology and Hepatology \u201cProf. Dr. Octavian Fodor\u201d  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0080-9972","authenticated-orcid":false,"given":"Andreea Maria","family":"Soporan","sequence":"additional","affiliation":[{"name":"Department of Personalized Medicine and Rare Diseases MEDFUTURE\u2014Institute for Biomedical Research \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"},{"name":"Department of Pharmaceutical Analysis Faculty of Pharmacy \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9516-0474","authenticated-orcid":false,"given":"Ioana Ecaterina","family":"Pralea","sequence":"additional","affiliation":[{"name":"Department of Personalized Medicine and Rare Diseases MEDFUTURE\u2014Institute for Biomedical Research \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4034-5471","authenticated-orcid":false,"given":"Horia","family":"Stefanescu","sequence":"additional","affiliation":[{"name":"Regional Institute of Gastroenterology and Hepatology \u201cProf. Dr. Octavian Fodor\u201d  Cluj\u2010Napoca 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