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Traditional diagnostic approaches relying on clinical assessment and biochemical markers often prove insufficient, necessitating advanced neuroimaging techniques for differential diagnosis. This review examines magnetic resonance imaging (MRI) techniques for differential diagnosis of HE and AD, focusing on T1\u2010weighted imaging findings characteristic of HE, and voxel\u2010based specific regional analysis system (VSRAD) applications in AD diagnosis. Analysis of the literature encompassed peer\u2010reviewed articles examining neuroimaging patterns, diagnostic accuracy, and clinical correlations in both HE and AD. T1\u2010weighted MRI displays bilateral symmetric hyperintensity at the globus pallidus in 70%\u201390% of HE patients attributed to manganese deposition secondary to impaired hepatic clearance, and provides evidence of HE\u2010related brain changes independent of ammonia levels. VSRAD analysis reveals characteristic medial temporal lobe atrophy patterns in AD, with diagnostic accuracy rates of 91.6% for very mild, 95.8% for mild, and 98.2% for moderate\u2010to\u2010severe AD. Clinical studies demonstrate that brain atrophy detected by VSRAD correlates significantly with functional impairment in activities of daily living, independent of conventional liver function parameters. The integration of T1\u2010weighted MRI and VSRAD analysis provides enhanced diagnostic accuracy for differentiating HE\u2010associated cognitive impairment from primary neurodegenerative conditions, offering valuable prognostic information regarding functional capacity and cognitive trajectory. This systematic neuroimaging approach enables more precise therapeutic decision\u2010making, signals treatment expectations, and directs rehabilitation planning and long\u2010term care strategies in an aging population with increasing prevalence of both hepatic and neurodegenerative disorders.<\/jats:p>","DOI":"10.1111\/hepr.70091","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T17:19:06Z","timestamp":1765300746000},"page":"11-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of MR Imaging Findings in Clinical Management of Hepatic Encephalopathy and Alzheimer's Disease"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6924-6485","authenticated-orcid":false,"given":"Soo Ryang","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Kobe Asahi Hospital  Kobe 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