{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:38:14Z","timestamp":1770136694826,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease characterized by diverse clinical and histological manifestations. Accurate histopathological evaluation plays a critical role in determining disease activity, guiding treatment strategies, and predicting prognosis. However, due to its broad histological spectrum, AIH can resemble other liver disorders such as drug\u2010induced liver injury (DILI) and viral hepatitis, making differential diagnosis challenging. In particular, acute\u2010onset AIH often lacks typical serological markers, further complicating timely diagnosis. Liver biopsy provides essential information that cannot be obtained through serological or imaging studies alone, such as the distribution and pattern of hepatic injury and the presence of bile duct involvement. Furthermore, with the increasing prevalence of metabolic dysfunction\u2010associated steatotic liver disease (MASLD), distinguishing AIH from overlapping or coexisting liver diseases has become increasingly important. This review highlights the characteristic histological features of AIH, discusses key differential diagnoses, and addresses current limitations in the diagnostic approach.<\/jats:p>","DOI":"10.1111\/hepr.70103","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T17:21:06Z","timestamp":1766164866000},"page":"139-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Autoimmune Hepatitis: Histopathological Diversity and Its Clinical Implications"],"prefix":"10.1111","volume":"56","author":[{"given":"Mina","family":"Komuta","sequence":"first","affiliation":[{"name":"Department of Anatomic Pathology International University of Health and Welfare School of Medicine  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Graduate School of Medicine Sciences Kanazawa University Kanazawa  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13342"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl19261"},{"key":"e_1_2_18_4_1","article-title":"Research Project on Intractable Diseases: \u2018Research on Intractable Liver and Biliary Tract Diseases\u2019 Groupministry of Health, Labour and Welfare","author":"Ministry of Health, Labour and Welfare","year":"2021","journal-title":"Guidelines for the Management of Autoimmune Hepatitis (AIH)"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001259"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2019.10.003"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840180435"},{"key":"e_1_2_18_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf02093820"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22322"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010018\u20101444\u20104"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath\u20102016\u2010204271"},{"key":"e_1_2_18_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.036"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872\u2010034x.2007.00150.x"},{"key":"e_1_2_18_14_1","first-page":"1","article-title":"Viral and Autoimmune Hepatitis. Morphologic and Pathogenetic Aspects of Cell Damage in Hepatitis With Potential Chronicity","volume":"132","author":"Dienes H. P.","year":"1989","journal-title":"Veroff Pathol"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524015666151026105411"},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072\u2010024\u201010714\u20101"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3513206"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15217"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0168\u20108278(97)80453\u20109"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22513"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24481"},{"key":"e_1_2_18_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2025.03.017"},{"key":"e_1_2_18_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.01.033"},{"key":"e_1_2_18_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.04.033"},{"key":"e_1_2_18_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.05.027"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23588"},{"key":"e_1_2_18_27_1","doi-asserted-by":"publisher","DOI":"10.14218\/jcth.2018.00053"},{"key":"e_1_2_18_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0168\u20108278(99)80297\u20109"},{"key":"e_1_2_18_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14195"},{"key":"e_1_2_18_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010020\u20100593\u20101"},{"key":"e_1_2_18_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.12.041"},{"key":"e_1_2_18_32_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0821"},{"key":"e_1_2_18_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280203"},{"key":"e_1_2_18_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2024.101224"},{"key":"e_1_2_18_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1148"},{"key":"e_1_2_18_36_1","doi-asserted-by":"publisher","DOI":"10.2957\/kanzo.66.1"},{"key":"e_1_2_18_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2001.03782.x"},{"key":"e_1_2_18_38_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i22.2809"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.70103","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hepr.70103","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.70103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T05:39:31Z","timestamp":1770097171000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.70103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/hepr.70103"],"URL":"https:\/\/doi.org\/10.1111\/hepr.70103","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]},"assertion":[{"value":"2025-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}