{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:08:23Z","timestamp":1778699303148,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Reports on the effects of hepatitis C virus (HCV) clearance through direct\u2010acting antiviral (DAA) administration after hepatocellular carcinoma (HCC) treatment on survival and recurrence rates in older patients remain limited. We examined the effects of DAA administration after HCC treatment in patients aged \u2265\u00a075\u00a0years on survival and recurrence rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This present retrospective multicenter study included patients aged \u2265\u00a075\u00a0years with HCV\u2010related HCC who received DAA within 12\u00a0months after HCC treatment (DAA group) and patients without DAA for HCV\u2010related HCC (non\u2010DAA group). Cases were classified as Barcelona Clinic Liver Cancer stage A or 0, limiting treatment method to liver resection and radiofrequency ablation. Propensity score matching was carried out, and patient\u2019s prognoses were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After matching, each group included 43 patients. In the DAA and non\u2010DAA groups, respectively, the 5\u2010year overall survival rates were 76.3% and 49.1% (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.024) whereas 5\u2010year cumulative recurrence rates were 61.7% and 92.4% (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Cox proportional hazards model (reporting hazard ratio and 95% confidence interval) showed DAA use as significantly associated with overall survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03; 0.47; and 0.23\u20130.93) and recurrence (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002; 0.45; and 0.27\u20130.74). The 5\u2010year median albumin\u2013bilirubin score was \u22122.77 (DAA group,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a016) and \u22122.36 (non\u2010DAA group,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a012) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002). DAA group had fewer deaths due to liver disease than non\u2010DAA group; however, the number of deaths due to nonliver diseases was almost same.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DAA improved hepatic reserve function and improved survival and recurrence rates after HCC treatment in patients aged \u2265\u00a075\u00a0years and should be administered after assessing the status of comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.70122","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T06:43:16Z","timestamp":1768200196000},"page":"744-752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Direct\u2010Acting Antivirals on Prognosis in Older Patients With Hepatitis C Virus\u2010Related Hepatocellular Carcinoma After Curative Therapy: A Retrospective Study by the Red Cross Liver Study Group in Japan"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1961-0899","authenticated-orcid":false,"given":"Hironori","family":"Ochi","sequence":"first","affiliation":[{"name":"Center for Liver\u2010Biliary\u2010Pancreatic Disease Matsuyama Red Cross Hospital  Matsuyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Kurosaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Musashino Red Cross Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Center for Liver\u2010Biliary\u2010Pancreatic Disease Matsuyama Red Cross Hospital  Matsuyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Akahane","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ishinomaki Red Cross Hospital  Ishinomaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Marusawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Kobashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Okayama Hospital  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Kyoto Daiichi Hospital  Kyoto 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