{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:34:48Z","timestamp":1784219688101,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP25K02635"],"award-info":[{"award-number":["JP25K02635"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Glecaprevir\/pibrentasvir (GLE\/PIB) and sofosbuvir\/ledipasvir (SOF\/LDV) are widely used as first\u2010line direct\u2010acting antiviral (DAA) regimens for chronic hepatitis C, achieving high virus eradication rates. However, a small proportion of patients experience treatment failure, and the optimal retreatment strategies for such cases remain unclear. This nationwide, multicenter, prospective study aimed to evaluate the efficacy of retreatment regimens in patients who failed initial DAA therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 330 patients were enrolled, including 117 with prior GLE\/PIB failure and 213 with prior SOF\/LDV failure. The primary outcome was sustained virologic response at 12\u00a0weeks after retreatment (SVR12). Retreatment regimens included 12\u00a0weeks of GLE\/PIB, sofosbuvir\/velpatasvir (SOF\/VEL) plus ribavirin (RBV), or SOF\/LDV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among patients retreated after GLE\/PIB failure, SVR12 rates were 99.0% (98\/99) with SOF\/VEL\u00a0+\u00a0RBV, 92.3% (12\/13) with GLE\/PIB 12\u00a0weeks, and 100% (5\/5) with SOF\/LDV, with no significant differences among regimens. Among patients retreated after SOF\/LDV failure, SVR12 rates were 100% (12\/12) with SOF\/VEL\u00a0+\u00a0RBV, 99.5% (197\/198) with GLE\/PIB 12\u00a0weeks, and 66.7% (2\/3) with SOF\/LDV. Retreatment of SOF\/VEL\u00a0+\u00a0RBV or GLE\/PIB demonstrated high therapeutic efficacy in patients with prior SOF\/LDV failure. One patient who relapsed after GLE\/PIB 8\u2010week therapy and harbored a P32del mutation achieved SVR12 with SOF\/VEL\u00a0+\u00a0RBV retreatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Retreatment with SOF\/VEL\u00a0+\u00a0RBV, GLE\/PIB for 12\u00a0weeks, or SOF\/LDV achieved high SVR12 rates, indicating that effective viral eradication is feasible using currently available DAA regimens even after prior treatment failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.70128","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T14:15:23Z","timestamp":1769696123000},"page":"778-783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Retreatment of Direct Acting Agents (DAAs) After Initial DAA Failure in Hepatitis C Patients"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4634-6616","authenticated-orcid":false,"given":"Nobuharu","family":"Tamaki","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Musashino Red Cross Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Kurosaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Musashino Red Cross Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1961-0899","authenticated-orcid":false,"given":"Hironori","family":"Ochi","sequence":"additional","affiliation":[{"name":"Center for Liver\u2010Biliary\u2010Pancreatic Disease Matsuyama Red Cross Hospital  Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Kyoto Daiichi Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3070-7387","authenticated-orcid":false,"given":"Yuichiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department of Internal Medicine Faculty of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7943-3842","authenticated-orcid":false,"given":"Takuya","family":"Sho","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Graduate School of Medicine Hokkaido University  Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2488-7315","authenticated-orcid":false,"given":"Hayato","family":"Hikita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The University of Osaka Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Marusawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9900-0064","authenticated-orcid":false,"given":"Yasuhiro","family":"Asahina","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Graduate School of Medical and Dental Science Institute of Science Tokyo (Science Tokyo)  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namiki","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Musashino Red Cross Hospital  Tokyo 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