{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:01:13Z","timestamp":1780754473503,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Abemaciclib, a cyclin\u2010dependent kinase 4\/6 inhibitor, is a standard treatment for hormone receptor\u2010positive and HER2\u2010negative breast cancer. However, liver dysfunction induced by abemaciclib is a significant clinical issue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report three cases of drug induced liver injury caused by abemaciclib with characteristic liver atrophy. Case 1: A woman in her seventies developed acute liver failure 2\u00a0months after initiation of letrozole and abemaciclib for breast cancer and bone metastases. A contrast\u2010enhanced CT (CECT) scan revealed liver atrophy accompanied by Chilaiditi syndrome. Despite steroid pulse therapy, she progressed to coma. Her liver failure improved, but she died due to worsening of the underlying disease. Case 2: A woman in her seventies developed liver dysfunction 2\u00a0months after initiation of anastrozole and abemaciclib to prevent recurrence. A CECT scan revealed liver atrophy and Chilaiditi syndrome. After admission, she progressed to acute liver failure and coma, and steroid pulse therapy was initiated. Hepatic encephalopathy improved with conservative treatment, and liver failure resolved with continued steroid administration. Case 3: A woman in her fifties. After breast cancer surgery, tamoxifen and abemaciclib were started as adjuvant therapy. Blood tests revealed liver dysfunction 2\u00a0months later. A CECT scan revealed liver atrophy and Chilaiditi syndrome, which improved with liver support therapy alone without progressing to liver failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusion<\/jats:title>\n                    <jats:p>This report is the first highlighting the imaging characteristics of rapid\u2010onset hepatic atrophy associated with abemaciclib\u2010induced liver injury. These findings may provide useful insights for distinguishing abemaciclib\u2010induced liver injury from other etiologies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.70148","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:10:39Z","timestamp":1772989839000},"page":"956-965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characteristic Hepatic Atrophy in Abemaciclib\u2010Induced Liver Injury: A Comparative Review of Three Cases"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2603-7054","authenticated-orcid":false,"given":"Yuwa","family":"Ando","sequence":"first","affiliation":[{"name":"Department of Gastroenterology St. Marianna University School of Medicine  Kawasaki Kanagawa 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