{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:19:48Z","timestamp":1788434388559,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:00:00Z","timestamp":1777680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:00:00Z","timestamp":1777680000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K03000"],"award-info":[{"award-number":["JP24K03000"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17H04095"],"award-info":[{"award-number":["JP17H04095"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Genetic polymorphisms of alcohol\u2010metabolizing enzymes influence drinking behavior and susceptibility to alcohol\u2010related liver disease (ALD). This study aimed to clarify the distribution of ALDH2 and ADH1B genotypes in liver transplant recipients with ALD, and to explore associations with post\u2010transplant drinking behavior using a recipient\u2013donor paired design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010four living donor liver transplant (LDLT) recipients with ALD, their corresponding living donors, and 50 healthy controls were analyzed. Single nucleotide polymorphisms of ALDH2 (rs671) and ADH1B (rs1229984) were determined by the Cycleave PCR method. Drinking behavior before and after transplantation was assessed by self\u2010report and electronic health records. Post\u2010transplant alcohol use was classified as habitual (\u2265 once per week) or occasional (&lt; once per week).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ALDH2 genotype distribution differed among three groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002), with enrichment of the ALDH2*1\/*1 genotype in ALD recipients (92%). ADH1B genotype distribution also differed among groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.041), although the effect size was modest. During a median follow\u2010up of 5.3\u00a0years (range, 0.3\u201315.9\u00a0years), 11 recipients (45%) reported post\u2010transplant alcohol use, including 5 habitual drinkers (20%). In an exploratory analysis, a non\u2010significant trend toward higher rates of habitual drinking was observed among recipients who received grafts from donors with the ALDH2*1\/*1 genotype compared with other genotypes (40% vs. 7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.12).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The ALDH2*1\/*1 genotype was more prevalent among liver transplant recipients with alcohol\u2010related cirrhosis than among donors or healthy controls, supporting a role of alcohol tolerance\u2013related genetic background in progression to end\u2010stage liver disease. Donor ALDH2 genotypes may also influence post\u2010transplant drinking behavior in an exploratory manner.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.70200","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:39:11Z","timestamp":1777736351000},"page":"1419-1425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ALDH2 Polymorphism in Alcohol\u2010Related Cirrhosis Requiring Liver Transplantation: A Recipient\u2013Donor Analysis"],"prefix":"10.1111","volume":"56","author":[{"given":"Noriyo","family":"Yamashiki","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kansai Medical University  Osaka Japan"},{"name":"Organ Transplantation Unit, Kyoto University Hospital  Sakyo\u2010ku Kyoto 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Hepato\u2010Biliary\u2010Pancreatic Surgery and Transplantation Department of Surgery Graduate School of Medicine Kyoto University  Kyoto 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