{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:56:21Z","timestamp":1791201381130,"version":"4.2.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the prognostic factors of hepatic steatosis detected using abdominal ultrasonography (AUS). After identifying low body mass index (BMI) as a potential risk factor, we explored the association between ultrasound\u2010detected hepatic steatosis (UDHS) and long\u2010term outcomes in underweight patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 8599 patients who underwent AUS from 2010 to 2015 at six medical centers. Patients with advanced liver disease or viral hepatitis were excluded. In Analysis 1, patients' baseline characteristics were compared between patients with and without UDHS. In Analysis 2, using Cox proportional hazards model, we assessed the risk factors for mortality among patients with UDHS. In Analysis 3, we conducted a propensity score\u2010matched analysis of patients with BMI &lt;\u00a018.5 to evaluate UDHS impact on survival and causes of death. Alcohol consumption data were unavailable; therefore, etiologic classification was not possible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Altogether, 2370 were diagnosed with UDHS. Male sex, low BMI, and diabetes mellitus were significantly associated with increased mortality among patients with UDHS. Among patients with BMI &lt;\u00a018.5, those with UDHS had significantly higher mortality rate than those without UDHS (43.8% vs. 14.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0035). Nonhepatic malignancy were the leading cause of death in this group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>UDHS in underweight patients was associated with worse prognosis in this exploratory matched analysis. This finding may suggest a higher\u2010risk subgroup and requires confirmation in larger prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.70220","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T09:29:36Z","timestamp":1782120576000},"page":"1509-1515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatic Steatosis Detected by Abdominal Ultrasonography Is Associated With Worse Prognosis in Underweight Patients"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4627-8721","authenticated-orcid":false,"given":"Makoto","family":"Higashino","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Saiseikai Matsuyama Hospital  Matsuyama City Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Saiseikai Matsuyama Hospital  Matsuyama City Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Okujima","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Saiseikai Matsuyama Hospital  Matsuyama City Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihide","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saiseikai Suita Hospital  Suita City Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Miyaoka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Saiseikai Matsuyama Hospital  Matsuyama City Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tokyo Saiseikai Central Hospital  Minato\u2010ku, Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5470-9694","authenticated-orcid":false,"given":"Toru","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saiseikai Niigata Hospital  Niigata City Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saiseikai Wakayama Hospital  Wakayama City Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fusao","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Hepatology Okayama Saiseikai General Hospital  Okayama City Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Horiike","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Saiseikai Imabari Dai\u2010ni Hospital  Imabari City Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Okanoue","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saiseikai Suita Hospital  Suita City Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000004"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102021\u2010325724"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010019\u20100972\u20106"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.02.11"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v16.i3.452"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3182779d49"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.16016"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X11430859"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1040\u20108428(00)00048\u20102"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15763"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603\u2010012\u20100434\u20100"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1217249"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154\u2010023\u201009796\u20103"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.70220","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hepr.70220","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.70220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:17:05Z","timestamp":1791199025000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.70220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/hepr.70220"],"URL":"https:\/\/doi.org\/10.1111\/hepr.70220","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"assertion":[{"value":"2025-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}