{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:58:47Z","timestamp":1791201527239,"version":"4.2.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n Although steatotic liver disease (SLD) has been associated with chronic kidney disease (CKD), it remains unclear whether CKD\u2010related outcomes are driven by hepatic steatosis itself or by accompanying cardiometabolic abnormalities. We investigated the relative contribution of hepatic steatosis and cardiometabolic risk factors to CKD\u2010related outcomes using a large Japanese health screening cohort.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In total, 30,648 SLD and 76,182 non\u2010SLD participants enrolled in the MIRACLE\u2010J cohort across 13 centers in Japan between 2014 and 2018 were analyzed. CKD\u2010related outcomes were defined as reduced estimated glomerular filtration rate (eGFR< 60\u00a0mL\/min\/1.73\u00a0m\n 2<\/jats:sup>\n ) and proteinuria. Multivariable logistic regression and trend analyses were performed to identify factors associated with these outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared with non\u2010SLD participants, those with SLD exhibited a higher burden of cardiometabolic abnormalities. Type 2 diabetes mellitus, obesity, and hyperuricemia were independently associated with proteinuria, whereas advanced age (\u2265\u00a065\u00a0years), low alcohol intake, and hyperuricemia were strongly associated with reduced eGFR. After multivariable adjustment, SLD showed an inverse association with CKD\u2010related outcomes. In both SLD and non\u2010SLD populations, the prevalence of CKD\u2010related outcomes increased stepwise with a higher number of cardiometabolic risk factors. Incorporation of hyperuricemia significantly improved model fit for reduced eGFR (\u0394\u22122 log likelihood\u00a0=\u00a0119.4,\n p<\/jats:italic>\n \u00a0<\u00a00.001) and modestly improved model fit for proteinuria (\n p<\/jats:italic>\n \u00a0=\u00a00.002).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n CKD\u2010related outcomes were more strongly associated with the burden of cardiometabolic abnormalities than with hepatic steatosis itself, and these associations were consistent in individuals with and without SLD. Hyperuricemia provided incremental value for renal risk stratification within this cardiometabolic framework, underscoring the importance of comprehensive metabolic risk assessment beyond liver fat status.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hepr.70224","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:01:11Z","timestamp":1786705271000},"page":"1535-1546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic Burden and Hyperuricemia Are Associated With CKD\u2010Related Outcomes in Individuals With and Without Steatotic Liver Disease"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7650-0699","authenticated-orcid":false,"given":"Michihiro","family":"Iwaki","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yokohama City University Graduate School of Medicine Yokohama 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