{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:17:56Z","timestamp":1783426676998,"version":"3.54.6"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25fk0210132"],"award-info":[{"award-number":["JP25fk0210132"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Reported cases of hepatitis E have increased in Japan; however, the true burden of hepatitis E virus (HEV) infection is likely underestimated due to the high proportion of asymptomatic infections. We prospectively evaluated anti\u2010HEV immunoglobulin G (IgG) seroprevalence, seroconversion\u2010based incidence, and questionnaire\u2010reported exposures in an occupational health\u2010checkup cohort in Mie Prefecture, central Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 608 individuals (189 men and 419 women) who underwent annual health checkups between fiscal years 2023 and 2025 were included. Serum anti\u2010HEV IgG was measured. At baseline, participants completed a 10\u2010item questionnaire on potential HEV\u2010related exposures. Incident infection was evaluated by identifying IgG seroconversion during follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Anti\u2010HEV IgG was detected in 5 of 608 participants (0.82%), all of whom were men (5\/189, 2.65% vs. 0\/419 women, 0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0028). Age was not significantly associated with IgG seropositivity. As no women were seropositive, exploratory age\u2010adjusted analyses were conducted among men only; no questionnaire item was significantly associated with IgG positivity. Sex differences were observed in reported consumption of pork liver\/offal, pork tongue, and venison\/wild boar meat. One participant seroconverted during follow\u2010up, corresponding to an incidence of 138 per 100,000 (1\/724; 95% CI, 3\u2013770) person\u2010years. The seroconverter reported frequent consumption of raw or undercooked pork products.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Anti\u2010HEV IgG seroprevalence was low in this relatively young, predominantly female cohort. However, prospective follow\u2010up identified incident infections, with an incidence consistent with previous domestic estimates, suggesting that a substantial proportion of the Japanese population remains at risk of HEV infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.70233","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:42:23Z","timestamp":1783424543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prospective Seroepidemiological Study of Hepatitis E Virus Infection in an Occupational Health\u2010Checkup Cohort in Mie Prefecture, Japan"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2682-3809","authenticated-orcid":false,"given":"Tatsunori","family":"Nakano","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Fujita Health University Nanakuri Memorial Hospital  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6888-9318","authenticated-orcid":false,"given":"Masaharu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Virology Department of Infection and Immunity Jichi Medical University School of Medicine  Shimotsuke Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Itani","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Fujita Health University Nanakuri Memorial Hospital  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiriha","family":"Suzaki","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Fujita Health University Nanakuri Memorial Hospital  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaho","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Fujita Health University Nanakuri Memorial Hospital  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Fujita Health University Nanakuri Memorial Hospital  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3419-6297","authenticated-orcid":false,"given":"Kazumoto","family":"Murata","sequence":"additional","affiliation":[{"name":"Division of Virology Department of Infection and Immunity Jichi Medical University School of Medicine  Shimotsuke Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0827-0964","authenticated-orcid":false,"given":"Hiroaki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Division of Virology Department of Infection and Immunity Jichi Medical University School of Medicine  Shimotsuke Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.001778"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28886"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17696"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/v18020220"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12175"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21678"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20215"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20393"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13961"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12121"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12868"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.14062"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1511.091094"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.43.1.49\u201056.2005"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2021.198355"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.14132"},{"key":"e_1_2_12_18_1","unstructured":"Statistics Bureau of Japan Family Income and Expenditure Survey 2023\u20102025 accessed May 30 2026 https:\/\/www.stat.go.jp\/data\/kakei\/5.html."},{"key":"e_1_2_12_19_1","unstructured":"Nippon Ham Foods Ltd \u201cConsumer Survey on Pork Consumption \u201d accessed May 30 2026 https:\/\/www.nipponham.co.jp\/corporate\/group\/report\/pdf\/241015.pdf."},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/v18060621"}],"container-title":["Hepatology 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