{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:49:02Z","timestamp":1782913742462,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to investigate the prognostic impact of the interval between curative\u2010intent local treatments in patients undergoing repeated therapies for recurrent hepatocellular carcinoma after hepatectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present retrospective cohort study included 890 patients who underwent hepatectomy for HCC at our hospital between 2001 and 2020. Overall survival (OS) was evaluated from the time of each curative\u2010intent local treatment, according to the number of treatments received and the intervals between consecutive curative\u2010intent treatments for intrahepatic recurrence, up to the fourth session.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During follow\u2010up, 625 patients (65.9%) developed intrahepatic recurrence. The median intervals gradually shortened to 24.9, 14.5, 12.4, and 12.8\u00a0months from hepatectomy to the first curative treatment, from the first to the second, from the second to the third, and from the third to the fourth treatments, respectively. For the first and second curative treatments, the pretreatment interval was not an independent predictor of OS. At the third curative treatment, an interval &lt; 18.6\u00a0months between the second and third curative treatments independently predicted poorer OS (hazard ratio [HR] 2.280 and 95% confidence interval [CI] 1.046\u20134.967). For the fourth curative treatment, an interval &lt; 14.1\u00a0months between the third and fourth treatments was an independent adverse prognostic factor (HR 4.961, 95% CI 1.607\u201315.319). The prognostic impact of treatment interval was more pronounced in patients who underwent \u2265 3 treatments, with a significant interaction compared with &lt; 3 treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among patients who remained eligible for repeated curative\u2010intent local treatment, a shortened interval between treatments in late\u2010phase recurrence was an independent predictor of poor prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.70235","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:23:09Z","timestamp":1782912189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment Interval as a Prognostic Marker in Patients Undergoing Repeated Curative\u2010Intent Local Treatment for Recurrent Hepatocellular Carcinoma"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6431-0011","authenticated-orcid":false,"given":"Katsunori","family":"Sakamoto","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Yoh","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9081-6430","authenticated-orcid":false,"given":"Satoshi","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Kadono","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenobu","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asahi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery Graduate School of Medicine Kyoto University  Kyoto 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Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5971-6173","authenticated-orcid":false,"given":"Shinya","family":"Okumura","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5708-6384","authenticated-orcid":false,"given":"Masayuki","family":"Okuno","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Nishino","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Yamane","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery Graduate School of Medicine Kyoto University  Kyoto 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