{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:12:00Z","timestamp":1784182320183,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012507"],"award-info":[{"award-number":["2023A1515012507"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obesity is a known risk factor for metabolic dysfunction\u2013associated steatotic liver disease (MASLD) and cirrhosis, but the long\u2010term effects of childhood thinness and body size changes across life are unclear. We aimed to assess how body size and child\u2010to\u2010adult body size trajectories relate to major liver outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 375,125 UK Biobank participants without liver disease at baseline. Childhood body size (thinner, average, and plumper) and adulthood body size (normal, overweight, and obesity) were combined into nine trajectories. Cox models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for incident MASLD and cirrhosis. Kaplan\u2013Meier survival curves assessed the association between body size trajectories and liver diseases. Sensitivity and subgroup analyses tested robustness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with average childhood body size, childhood thinness was associated with higher risks of MASLD (HR 1.18, 95% CI 1.11\u20131.27) and cirrhosis (HR 1.15, 95% CI 1.03\u20131.27). Relative to persistently normal body size, the \u201cthinner to obesity\u201d trajectory showed the greatest risks of MASLD (HR 3.95, 95% CI 3.29\u20134.76) and cirrhosis (HR 3.97, 95% CI 3.30\u20134.77). The \u201cplumper to normal\u201d trajectory was not associated with increased MASLD or cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Childhood thinness is associated with increased risks of MASLD and cirrhosis in adulthood. Achieving a normal BMI in adulthood may mitigate liver\u2010related risks linked to childhood overweight.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.70238","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:56:02Z","timestamp":1784181362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Childhood Underweight and Adulthood Obesity Associated With Increased Risk of MASLD and Cirrhosis: A Prospective Cohort Study of 375,125 Adults"],"prefix":"10.1111","author":[{"given":"Jiadong","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Endocrinology Zhujiang Hospital of Southern Medical University  Guangzhou Guangdong China"},{"name":"Sanshui Hospital Zhujiang Hospital of Southern Medical University  Foshan Guangdong 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