{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:03:55Z","timestamp":1784347435225,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["JPMH23FC1026"],"award-info":[{"award-number":["JPMH23FC1026"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015993","name":"Kowa Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015993","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014421","name":"EA Pharma Co., Ltd.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Primary biliary cholangitis (PBC) frequently impairs health\u2010related quality of life (HRQOL); however, longitudinal changes in symptoms and their relationship with prognosis remain unclear. We aimed to elucidate the current status of symptoms and HRQOL in Japanese patients with PBC, evaluate 10\u2010year changes in PBC\u201040 scores, and examine associations with long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter observational study comprised three analyses: (i) a 2025 cross\u2010sectional study assessing associations between clinical parameters, PBC\u201040 (symptom indicators), and EQ\u20105D\u20105\u00a0L (HRQOL indicators); (ii) a longitudinal PBC\u201040 study comparing scores from 2015 to 2025; and (iii) a longitudinal outcome study evaluating 2015 PBC\u201040 scores and clinical parameters in relation to survival through 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 2025%, 20%\u201350% of all patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0239) had moderate\/severe PBC\u201040 scores in each domain. EQ\u20105D\u20105L scores were significantly lower in women &lt;\u00a059\u00a0years versus general population, with multivariable analysis identifying itch, fatigue, and social domains as independent contributors to impaired HRQOL. Across a 10\u2010year follow\u2010up, overall significant deterioration was observed in symptoms (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0015), itch (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0039), and cognitive (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0011) domains, while interindividual variability was greatest in itch and emotional and smallest in symptoms. In longitudinal outcome study (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0410), no PBC\u201040 domain predicted death or liver transplantation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HRQOL in patients with PBC was significantly impaired in younger female. Over 10\u00a0years, overall and interindividual changes in domain scores greatly varied, suggesting that symptom burdens are driven by heterogeneous underlying mechanisms. HRQOL impairment represents distinct dimensions of disease impact in PBC, independently of long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.70246","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:37:21Z","timestamp":1784345841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stability and Variability of Symptom Burden in Primary Biliary Cholangitis: Insights From a Decade of Follow\u2010Up"],"prefix":"10.1111","author":[{"given":"Akihito","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Department of Medicine Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2607-9381","authenticated-orcid":false,"given":"Atsumasa","family":"Komori","sequence":"additional","affiliation":[{"name":"Clinical Research Center National Hospital 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