{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T16:44:43Z","timestamp":1785689083433,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25fk0210121"],"award-info":[{"award-number":["JP25fk0210121"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["20H05675"],"award-info":[{"award-number":["20H05675"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["22H02967"],"award-info":[{"award-number":["22H02967"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hepatology Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Patients with chronic hepatitis C and advanced fibrosis remain at substantial risk of hepatocellular carcinoma (HCC) and non\u2010liver\u2013related death even after sustained virological response (SVR) to direct\u2010acting antivirals (DAA). Serum agalactosyl IgG (agal\u2010IgG) reflects chronic inflammation and fibrogenic activity, but its prognostic value after SVR is unknown. We investigated whether serum agal\u2010IgG at end of treatment (EOT) predicts HCC and all\u2010cause mortality in DAA\u2010treated patients with advanced fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among 3550 patients with chronic hepatitis C treated with DAAs at Osaka University Hospital and affiliated centers, the stored sera of 136 patients with biopsy\u2010proven F3\u2013F4 fibrosis before DAA treatment, who achieved SVR, and had no history of HCC were available at EOT. Serum agal\u2010IgG at EOT was measured using a 42B1\u2010based ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During a median follow\u2010up of 68.7\u00a0months (interquartile range, 36.8\u201384.9) for HCC surveillance, 15 patients developed HCC. Over a median overall follow\u2010up of 73.7\u00a0months (54.5\u201386.7), 11 patients died. Higher EOT agal\u2010IgG levels were significantly associated with both HCC occurrence and all\u2010cause mortality, and these associations remained independent after adjustment for age, sex, and baseline fibrosis (FIB\u20104 index). The adjusted hazard ratios per 1\u2010unit increase in agal\u2010IgG were 1.050 (95% CI, 1.008\u20131.094) for HCC and 1.085 (95% CI, 1.035\u20131.137) for all\u2010cause mortality. Patients with EOT agal\u2010IgG levels above the cohort median also showed significantly higher cumulative incidences of HCC and all\u2010cause death than those with lower levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum agalactosyl IgG measured at the end of DAA therapy independently predicts HCC and all\u2010cause mortality after SVR in patients with chronic hepatitis C and advanced fibrosis. EOT agal\u2010IgG may offer additional prognostic information for post\u2010SVR risk stratification and help identify patients at higher risk of HCC and all\u2010cause mortality after SVR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hepr.70255","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:50:39Z","timestamp":1785685839000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Agalactosyl IgG Predicts Hepatocellular Carcinoma and All\u2010Cause Mortality After SVR in Advanced Chronic Hepatitis C"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7507-2998","authenticated-orcid":false,"given":"Daisuke","family":"Sakon","sequence":"first","affiliation":[{"name":"Department of Molecular Biochemistry and Clinical Investigation The University of Osaka Graduate School of Medicine  Suita Osaka 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Medicine  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Iwaisako","sequence":"additional","affiliation":[{"name":"Department of Molecular Biochemistry and Clinical Investigation The University of Osaka Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muya","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Molecular Biochemistry and Clinical Investigation The University of Osaka Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Molecular Biochemistry and Clinical Investigation The University of Osaka Graduate School of Medicine  Suita Osaka 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